Diffusion-weighted MRI findings in Sjögren's syndrome: a preliminary study

Acta Radiologica
Changwei DingHuadong Cui

Abstract

Parotid glands diffusion-weighted imaging (DWI) in Sjögren's syndrome patients have provided conflicting results currently. To determine if parotid gland DWI using a small region of interest (ROI) can provide diagnosis and assess therapeutic efficacy in Sjögren's syndrome. Twenty-three women with Sjögren's syndrome, five with dry mouth who did not meet diagnostic criteria for Sjögren's syndrome, and 11 healthy volunteers (controls) were evaluated with DWI. All participants received routine T1-weighted (T1W) imaging and T2-weighted (T2W) fat-suppressed imaging, and DWI. The SI ratios (SIRs) and ADC ratios (ADCRs) for parotid gland/spinal cord were then calculated. Approximately 8-10 round ROIs measuring approximately 5 mm(2) were placed on each lobe of the parotid gland, and the signal intensity (SI) was measured while avoiding fat, ducts, and blood vessels. A ROI encompassing the entire lobe of the parotid gland was also used to measure SI. Using 5 mm(2) ROIs significantly higher DWI SIRs were noted in participants with Sjögren's syndrome compared with either participants with dry mouth without Sjögren's syndrome or healthy volunteers (all, P <0.001). The difference was not related to the presence of fat. No differences were no...Continue Reading

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Citations

Jan 7, 2017·The Neuroradiology Journal·Ahmed Abdel Khalek Abdel Razek, Suresh Mukherji
Mar 23, 2017·Journal of Magnetic Resonance Imaging : JMRI·Chen ChuZhengyang Zhou
Oct 12, 2016·Journal of Magnetic Resonance Imaging : JMRI·Chen ChuZhengyang Zhou
Jul 20, 2017·Journal of Computer Assisted Tomography·Chen ChuZhengyang Zhou
Apr 28, 2021·Magnetic Resonance Imaging Clinics of North America·Felix BoucherAshok Srinivasan

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