Diffusion-weighted MRI in severe neonatal hypoxic ischaemia: the white cerebrum

Neuropediatrics
R Jeroen VermeulenFrederik Barkhof

Abstract

Presently, prognosis of infants with perinatal hypoxia-ischaemia is estimated using the Sarnat scale, which combines clinical evaluation and electroencephalography, in combination with magnetic resonance imaging (MRI) and or evoked potentials. While the value of conventional MRI is limited during the first week of life, diffusion-weighted MRI demonstrates effects of acute cerebral ischaemia within hours of onset. However, the exact value of diffusion MRI in the prognosis of infants with hypoxia-ischaemia has to be established in larger follow-up studies. In this report we describe 5 term (post-conceptional age 40 1/7 to 41 2/7 week) neonates with severe hypoxia-ischaemia and a characteristic pattern of diffusion changes. T 1 -weighted images showed a hyperintense cortical signal in only one case and extensive hyperintensity in the basal nuclei in all 5 cases. T 2 -weighted images showed nearly complete loss of cortical delineation in three cases. Increased signal on diffusion-weighted images was seen throughout all cortical and subcortical areas while the cerebellum remained normal. This pattern, which we refer to as the "white cerebrum", is most readily apparent on coronal images. The apparent diffusion coefficient (ADC) was c...Continue Reading

Citations

Jan 5, 2013·Pediatric Radiology·Duan XuA James Barkovich
Jun 12, 2013·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Tina BregantIvica Kostovic
Nov 23, 2012·Archives of Disease in Childhood. Fetal and Neonatal Edition·Thomas AlderliestenFloris Groenendaal
Apr 15, 2010·Neuroradiology·Linda S de Vries, Floris Groenendaal
Jul 16, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sonia K GheiIzlem Izbudak
Mar 1, 2011·Expert Opinion on Medical Diagnostics·Topun Austin, Helen O'Reilly
Mar 11, 2016·Journal of Pediatric Neurosciences·Manipriya RavindranBinu Ninan
Jun 29, 2004·Journal of Magnetic Resonance Imaging : JMRI·Berit H MunkebyAtle Bjørnerud
Sep 20, 2011·Early Human Development·Sylke J SteggerdaGerda van Wezel-Meijler
Sep 15, 2009·Pediatric Neurology·Jacqueline S CoatsStephen Ashwal
Feb 3, 2009·Acta Paediatrica·Renate SwartePaul Govaert
Nov 6, 2012·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E LoprioreM J Benders
May 7, 2009·Developmental Medicine and Child Neurology·Petra E M van SchieR Jeroen Vermeulen
Feb 15, 2005·Early Human Development·Mary RutherfordSerena Counsell
Jun 28, 2005·Seminars in Fetal & Neonatal Medicine·Mary A RutherfordChristine Malamatentiou
Apr 23, 2015·European Radiology·S J SteggerdaG van Wezel-Meijler
Aug 25, 2016·Archives of Disease in Childhood. Fetal and Neonatal Edition·Thomas AlderliestenFloris Groenendaal
Dec 23, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sachiko KoshinoKei Yamada
Sep 29, 2020·Stem Cells Translational Medicine·Ruth GussenhovenReint K Jellema
May 24, 2017·Frontiers in Cellular Neuroscience·Lancelot J MillarZoltán Molnár

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.