Diffusion-weighted MRI in transient global amnesia and its diagnostic implications.

Neurology
Kristina SzaboA Gass

Abstract

To analyze how the evidence of hippocampal diffusion-weighted imaging (DWI) lesions may support the clinical diagnosis of transient global amnesia (TGA). In this retrospective observational study, 390 consecutive patients with isolated TGA were analyzed, who were evaluated at our institution between July 1999 and August 2018. The size, location, and number of lesions and time-dependent lesion detectability were examined. The incidence of DWI lesions was reviewed with regard to different levels of clinical diagnostic certainty upon presentation to the emergency department. Hippocampal DWI lesions were detected in 272 (70.6%) patients with TGA, with a mean of 1.05 ± 0.98 (range 0-6) and a mean lesion size of 4.01 ± 1.22 mm (range 1.7-8.6 mm). In the subgroups of lower diagnostic certainty (amnesia witnessed by layperson or self-reported amnestic gap), DWI was helpful in supporting the diagnosis of TGA in 76 (69.1%) patients. In 187 patients with information about the exact onset, DWI lesions were analyzed in relation to latency between onset and MRI. Lesions could be detected at all time points and up to 6 days after symptom onset in individual patients; the highest rate of DWI-positive MRI (93%) was in the 12-24 hours time windo...Continue Reading

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Citations

Jun 3, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C HoyerK Szabo
Feb 9, 2021·Reviews in the Neurosciences·Ioannis LiampasEfthimios Dardiotis
Mar 7, 2021·Reviews in the Neurosciences·Ioannis LiampasEfthimios Dardiotis
Apr 7, 2021·Clinical Imaging·Sung-Hye YouBo Kyu Kim
May 23, 2021·Journal of Neuropsychology·Vesile SandikciKristina Szabo
Jul 17, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Su Jin LimSang Joon Kim
Jul 27, 2021·Frontiers in Neurology·Andreas RogalewskiWolf-Rüdiger Schäbitz
May 25, 2021·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Luis Rafael Solís TarazonaCarmen María Sanchis Llopis
Sep 14, 2021·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Matthew L WongNicole M Dubosh
Feb 3, 2022·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Matthias WittayerKristina Szabo

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