Diffusional kurtosis imaging and white matter microstructure modeling in a clinical study of major depressive disorder

NMR in Biomedicine
Kouhei KamiyaOsamu Abe

Abstract

Major depressive disorder (MDD) is a globally prevalent psychiatric disorder that results from disruption of multiple neural circuits involved in emotional regulation. Although previous studies using diffusion tensor imaging (DTI) found smaller values of fractional anisotropy (FA) in the white matter, predominantly in the frontal lobe, of patients with MDD, studies using diffusion kurtosis imaging (DKI) are scarce. Here, we used DKI whole-brain analysis with tract-based spatial statistics (TBSS) to investigate the brain microstructural abnormalities in MDD. Twenty-six patients with MDD and 42 age- and sex-matched control subjects were enrolled. To investigate the microstructural pathology underlying the observations in DKI, a compartment model analysis was conducted focusing on the corpus callosum. In TBSS, the patients with MDD showed significantly smaller values of FA in the genu and frontal portion of the body of the corpus callosum. The patients also had smaller values of mean kurtosis (MK) and radial kurtosis (RK), but MK and RK abnormalities were distributed more widely compared with FA, predominantly in the frontal lobe but also in the parietal, occipital, and temporal lobes. Within the callosum, the regions with smaller...Continue Reading

References

Dec 11, 1992·Brain Research·F AboitizE Zaidel
Jan 26, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Keith Wachowicz, Richard E Snyder
May 14, 2005·Nature Reviews. Neuroscience·E Ron de KloetFlorian Holsboer
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jens H JensenKyle Kaczynski
Oct 1, 2005·Psychiatry and Clinical Neurosciences·Tempei OtsuboKunitoshi Kamijima
Sep 26, 2006·NMR in Biomedicine·Isidro Bonilla, Richard E Snyder
Jan 4, 2008·The New England Journal of Medicine·R H Belmaker, Galila Agam
Apr 15, 2008·International Clinical Psychopharmacology·Janet B W WilliamsAmir Kalali
Jul 29, 2008·Magnetic Resonance Imaging·Markus NilssonSara Brockstedt
Jun 29, 2010·NeuroImage·Daniel C AlexanderTim B Dyrby
Jul 16, 2010·NMR in Biomedicine·Jens H Jensen, Joseph A Helpern
Sep 2, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Richard D DortchMark D Does
Oct 1, 2010·NMR in Biomedicine·Els FieremansJoseph A Helpern
Oct 5, 2010·NMR in Biomedicine·Dmitry S Novikov, Valerij G Kiselev
Mar 19, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jelle VeraartJan Sijbers
Jun 28, 2011·NeuroImage·Els FieremansJoseph A Helpern
Sep 13, 2011·Trends in Cognitive Sciences·Vinod Menon
Oct 18, 2011·NeuroImage·Eleftheria PanagiotakiDaniel C Alexander
Mar 10, 2012·Radiology·Sofie Van CauterStefan Sunaert
Jul 28, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Markus NilssonDaniel Topgaard
Feb 5, 2013·Frontiers in Integrative Neuroscience·Matthew D Budde, Jacopo Annese
Dec 3, 2014·Biological Psychiatry·Qiyong Gong, Yong He
Apr 29, 2015·Magnetic Resonance Imaging·Joseph GoveasMarco Giannelli
May 26, 2015·NeuroImage·Nikola StikovG Bruce Pike
Oct 21, 2015·NeuroImage·Jesper L R Andersson, Stamatios N Sotiropoulos
Nov 26, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jelle VeraartDmitry S Novikov
Nov 27, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Brian HansenSune Nørhøj Jespersen
Dec 1, 2015·NMR in Biomedicine·Ileana O JelescuDmitry S Novikov
Jan 9, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Elias KellnerMarco Reisert
Feb 9, 2016·Human Brain Mapping·Danilo ArnoneAndrew M McIntosh
Apr 15, 2016·Journal of Neurology, Neurosurgery, and Psychiatry·G Russell GlennLeonardo Bonilha
Jun 9, 2016·Physics in Medicine and Biology·K D Harkins, M D Does
Jun 11, 2016·NeuroImage·Enrico KadenDaniel C Alexander

❮ Previous
Next ❯

Citations

Aug 29, 2019·Translational Psychiatry·Li WangTian-Mei Si

❮ Previous
Next ❯

Software Mentioned

MATLAB
MRTrix3
TBSS
FSL
RotInv
FMRIB Software Library FSL

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.