PMID: 4887135Jul 1, 1968Paper

Diffusional resistance of the innermost layer of the placental barrier of the rabbit

The Journal of Physiology
J J FaberA C Poutala

Abstract

1. The permeability of the endothelial cell layer of the foetal capillaries of the rabbit placenta was measured by the tracer-dilution method. Isotopically labelled water, urea, chloride and sodium ions, and inulin were used. Radio-iodinated human serum albumin served as reference tracer. The measurements were made in in situ placentas of 27-29 days gestation of which the foetal circulation was perfused with homologous blood.2. The permeability of water was found to be 1.7 ml. min(-1).g(-1), the permeabilities of urea, chloride ions and sodium ions were in the range of 0.28-0.42 ml. min(-1).g(-1) and the permeability of inulin was 0.053 ml. min(-1).g(-1). These values may be underestimates, particularly the value of water.3. The approximate maternal blood space, foetal blood space, and extravascular sodium space were determined in rabbit placentas of 27-29 days gestation and found to be 0.16, 0.07, and 0.48 ml./g respectively.4. The permeabilities of the endothelial layer were compared to those published for the entire placenta and found to be far greater. The resistance to diffusion of the endothelial layer is only a small part of the total resistance to diffusion. Most of the resistance is localized in the syncytioand/or cell...Continue Reading

Citations

Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Jan 1, 1969·Pflügers Archiv : European journal of physiology·J J Faber, R S Stearns
Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·B P Setchell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.