Diffusive transport of molecular cargo tethered to a DNA origami platform

Nano Letters
Enzo KoppergerFriedrich C Simmel

Abstract

Fast and efficient transport of molecular cargoes along tracks or on supramolecular platforms is an important prerequisite for the development of future nanorobotic systems and assembly lines. Here, we study the diffusive transport of DNA cargo strands bound to a supramolecular DNA origami structure via an extended tether arm. For short distances (on the order of a few nanometers), transport from a start to a target site is found to be less efficient than for direct transfer without tether. For distances on the scale of the origami platform itself, however, cargo transfer mediated by a rigid tether arm occurs very fast and robust, whereas a more flexible, hinged tether is found to be considerably less efficient. Our results suggest diffusive motion on a molecular tether as a highly efficient mechanism for fast transfer of cargoes over long distances.

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Citations

Jun 2, 2015·Nano Letters·Benjamin KickDirk Weuster-Botz
Sep 10, 2016·Nano Letters·Aradhana ChopraFriedrich C Simmel
Apr 18, 2017·ACS Synthetic Biology·Jerzy KozyraNatalio Krasnogor
Jan 20, 2018·Science·Enzo KoppergerFriedrich C Simmel
Apr 6, 2018·Annual Review of Biomedical Engineering·Yonggang KeJong Hyun Choi
Nov 7, 2018·Nature Materials·Jie ChaoChunhai Fan
Mar 26, 2019·Small·Fei WangQian Li
Apr 6, 2020·Topics in Current Chemistry·Jinglin FuTing Zhang
Aug 14, 2019·Chemical Society Reviews·Wenjing WangJun-Jie Zhu
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Jan 22, 2019·Nature Chemistry·Lifei ZhengWilhelm T S Huck
Apr 2, 2020·Analytical and Bioanalytical Chemistry·Jinyi WangJianzhong Lu
Apr 20, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Hui LvFei Wang
Jun 13, 2017·Chemical Reviews·Fan HongHao Yan
Sep 21, 2019·Journal of the American Chemical Society·Cheng ZhangHao Yan
Apr 3, 2018·Nano Letters·Alessia AmodioFrancesco Ricci
Aug 29, 2019·ACS Omega·Ruizheng HouZhisong Wang
Feb 5, 2019·Chemical Reviews·Friedrich C SimmelHari R Singh
Jan 23, 2018·ACS Nano·Hieu BuiJohn Reif

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