PMID: 8967381Apr 1, 1996Paper

Diffusivity of oxygen in microvascular beds as determined from PO2 distribution maps

The American Journal of Physiology
K YaegashiT Morimoto

Abstract

Dynamic changes in the distribution of PO2 in the rat mesentery were measured to determine the O2 diffusion coefficient (DO2) and consumption rate (VO2). The distribution of PO2 was obtained in two-dimensional maps by microscopic fluorometry on the basis of oxygen quenching. The corresponding vasculature was also recorded on a video recorder to analyze the PO2 distribution consistent with the arrangement of the microvessels. Anesthetized rats breathing room air were subjected to 100% O2 ventilation to induce dynamic changes in PO2 distribution. We assumed a homogenous and constant VO2 in the tissue, and a one-dimensional diffusion equation was applied to simulate oxygen transport. The PO2 data corresponded very well to the theoretical curves, and calculated DO2 was 1.04 +/- 0.78 X 10(-5) cm2/s (mean +/- SD, n = 38) and VO2 was 8.2 +/- 3.9 x 10(-6) cm3 O2.cm-3 tissue.s-1 (n = 27) at 37 degrees C. However, PO2 values at points remote from the arterioles remained higher than the theoretical prediction.

Citations

May 8, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Aleksander S GolubRoland N Pittman
Jun 28, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Markus PaxianMark G Clemens
Sep 29, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Bettina ReglinAxel R Pries
Jul 5, 2003·Physiological Reviews·Amy G TsaiMarcos Intaglietta
Oct 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Aleksander S GolubRoland N Pittman
Aug 3, 2000·Journal of Biomechanical Engineering·R E McClelland, R N Coger

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