Diflunisal-adjoined cobalt(iii)-polypyridyl complexes as anti-cancer stem cell agents

Dalton Transactions : an International Journal of Inorganic Chemistry
David O AbeKogularamanan Suntharalingam

Abstract

We report a novel series of cobalt(iii)-polypridyl complexes, 4-6, that can selectively release diflunisal, a nonsteroidal anti-inflammatory drug, under reducing conditions. Remarkably, the 1,10-phenanthroline-bearing complex 5 displays selective potency towards hard-to-kill cancer stem cells (CSCs) (IC50 = 2.1 ± 0.1 μM) over bulk cancer (IC50 = 3.9 ± 0.2 μM) and normal cells (IC50 = 21.2 ± 1.3 μM). This complex induces CSC apoptosis by DNA damage and cyclooxygenase-2 inhibition.

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Citations

Jun 19, 2019·Angewandte Chemie·Arvin EskandariKogularamanan Suntharalingam
May 13, 2020·Journal of Cellular Physiology·Yang LiuBin Liu
Oct 17, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Daniel BaeckerRonald Gust
Oct 1, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Yingsi LiQianling Zhang

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Datasets Mentioned

BETA
GM07575
GMO7575

Methods Mentioned

BETA
column chromatography

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