Difructose anhydride III enhances bioavailability of water-insoluble iron in anemic Vietnamese women

Journal of Nutritional Science and Vitaminology
Masayo NakamoriShigeru Yamamoto

Abstract

Difructose anhydride III (DFAIII) is an indigestible disaccharide and has been shown to enhance iron absorption in animal studies; however, the effect has not been investigated in anemic subjects. We investigated the efficacy of co-administration of DFAIII with water-insoluble iron in the treatment of iron deficiency anemia in Vietnamese women. One hundred sixty-eight moderately anemic women (80 g/L<hemoglobin (Hb)<120 g/L) participated in a double-blinded, placebo-controlled study with daily supplementation of iron for 6 mo. The volunteers were randomly assigned into four groups, i.e., Group A: received 15 mg Fe as ferric pyrophosphate; Group B: received 15 mg Fe as ferric pyrophosphate and 1.25 g DFAIII; Group C: received 15 mg Fe as ferrous sulfate; Group D: received a placebo. Hb and iron status were measured at baseline and after 2, 4 and 6 mo of intervention. The ratio of transferrin receptor to ferritin was used to estimate stored and functional body iron (BI). One hundred sixteen (69.0%) women completed the trial. After 6 mo, mean (+/-SE) Hb concentration was higher in Group A (121.6+/-1.7 g/L), Group B (126.4+/-1.5 g/L) and Group C (126.8+/-1.6 g/L) compared to Group D (107.0+/-1.7 g/L, p<0.0001). Mean change in BI was...Continue Reading

References

Jan 1, 1991·Clinical and Laboratory Haematology·M WorwoodJ D Cook
Jul 1, 1990·American Journal of Hematology·D KlemowB S Skikne
Aug 1, 1990·British Journal of Haematology·J D CookB S Skikne
Sep 1, 1966·Acta Oto-laryngologica·J Tarkkanen, M Tuomioja
Aug 17, 2000·Bioscience, Biotechnology, and Biochemistry·K Saito, F Tomita
Jan 11, 2003·Blood·James D CookBarry S Skikne
Jun 1, 2004·Bioscience, Biotechnology, and Biochemistry·Norihiro ShigematsuHiroshi Hara
Mar 9, 2006·The American Journal of Clinical Nutrition·Diego MorettiRichard F Hurrell
Dec 22, 2006·The Journal of Nutrition·Mary Frances LynchSteven A Abrams
Mar 8, 2007·Bioscience, Biotechnology, and Biochemistry·Kyoko TomitaHiroshi Hara
May 24, 2008·Public Health Nutrition·Erin McLeanBruno de Benoist

❮ Previous
Next ❯

Citations

Nov 29, 2014·Applied Microbiology and Biotechnology·Xiao WangWanmeng Mu
Feb 25, 2018·Applied Microbiology and Biotechnology·Yingying ZhuWanmeng Mu
Mar 21, 2019·Current Pharmaceutical Design·Dan WanYulong Yin
Mar 30, 2021·Critical Reviews in Food Science and Nutrition·Mei ChengWanmeng Mu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.