Digesting a Path Forward: The Utility of Collagenase Tumor Treatment for Improved Drug Delivery

Molecular Pharmaceutics
Aaron Dolor, Francis C Szoka

Abstract

Collagen and hyaluronan are the most abundant components of the extracellular matrix (ECM) and their overexpression in tumors is linked to increased tumor growth and metastasis. These ECM components contribute to a protective tumor microenvironment by supporting a high interstitial fluid pressure and creating a tortuous setting for the convection and diffusion of chemotherapeutic small molecules, antibodies, and nanoparticles in the tumor interstitial space. This review focuses on the research efforts to deplete extracellular collagen with collagenases to normalize the tumor microenvironment. Although collagen synthesis inhibitors are in clinical development, the use of collagenases is contentious and clinically untested in cancer patients. Pretreatment of murine tumors with collagenases increased drug uptake and diffusion 2-10-fold. This modest improvement resulted in decreased tumor growth, but the benefits of collagenase treatment are confounded by risks of toxicity from collagen breakdown in healthy tissues. In this review, we evaluate the published in vitro and in vivo benefits and limitations of collagenase treatment to improve drug delivery.

References

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·K BeckenlehnerW Schiess
Aug 1, 1989·The Journal of Investigative Dermatology·K S StennE Kuklinska
Apr 18, 1998·The Biochemical Journal·W KafienahA P Hollander
Oct 29, 1998·Protein Expression and Purification·N PathakJ A Koehn
Oct 18, 2000·Critical Reviews in Oncology/hematology·G Fracasso, M Colombatti
Jun 8, 2001·The American Journal of Pathology·S ZuckerB P Toole
Jul 13, 2001·Clinical & Experimental Metastasis·Y YonemuraT Sasaki
Dec 5, 2002·Burns : Journal of the International Society for Burn Injuries·Coşkun OzcanGeylani Ozok
Oct 14, 2003·Applied Microbiology and Biotechnology·K Watanabe
Apr 21, 2005·Thrombosis and Haemostasis·Jian CaoHoward L Adler
Aug 13, 2005·Advances in Genetics·Hui-Wen LoMien-Chie Hung
Mar 23, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jaehwa ChoiMichael F Flessner
May 30, 2006·Biochemical and Biophysical Research Communications·Hajime MorohashiKeiichi Takagaki
Aug 1, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·L H BookbinderG I Frost
Jul 27, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jin ChengJohn G Hay
Sep 1, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mazin MagzoubA S Verkman
Jul 22, 2008·Microvascular Research·Yaron HassidHadassa Degani
Apr 14, 2010·Circulation·Begoña LópezJavier Díez
Sep 15, 2010·Nature Reviews. Clinical Oncology·Rakesh K Jain, Triantafyllos Stylianopoulos
Nov 23, 2010·The FEBS Journal·Elin Hadler-OlsenJan-Olof Winberg
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Benjamin Diop-FrimpongRakesh K Jain
Sep 16, 2011·Cold Spring Harbor Perspectives in Biology·Pengfei LuZena Werb
Nov 5, 2011·Cancer Discovery·Clifford J WhatcottDaniel D Von Hoff
Dec 27, 2011·International Journal of Pharmaceutics·Mako KatoYoshie Maitani
May 11, 2012·The Journal of Biological Chemistry·Caitlin J FoleyAthan Kuliopulos
Sep 21, 2012·The Journal of Biological Chemistry·Yasusei KudoTakashi Takata
Sep 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jieqiong LiuLei Xu
Oct 6, 2012·Advanced Drug Delivery Reviews·Vincent J Venditto, Francis C Szoka

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Citations

Nov 1, 2018·Journal of Cellular Physiology·Masoud NajafiKeywan Mortezaee
May 22, 2020·Journal of Translational Medicine·Anette Hauge, Einar K Rofstad
Apr 8, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Dean HoTheodore Kee
Dec 11, 2020·Nano Convergence·Julia SalapaJoseph Irudayaraj
Dec 12, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lu ZhangXian-Rong Qi
Jan 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Shizhen GengJie Zhou
Feb 13, 2021·Journal of Personalized Medicine·Nithya Subrahmanyam, Hamidreza Ghandehari
Jan 28, 2019·Biochemical and Biophysical Research Communications·Keith S AbayasiriwardanaSteven E Mutsaers
Apr 6, 2021·Current Tissue Microenvironment Reports·Praveen Krishna VeerasubramanianTimothy L Downing
Apr 24, 2021·Signal Transduction and Targeted Therapy·Jiacheng HuangYiting Qiao
Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Suah YangKwangmeyung Kim
Jun 29, 2021·Advanced Drug Delivery Reviews·Sofie SnipstadCatharina de Lange Davies
Aug 6, 2021·Drug Delivery and Translational Research·Seung Woo ChungJung Soo Suk
Sep 12, 2021·Proceedings of the National Academy of Sciences of the United States of America·Dhiraj KumarSridhar Nimmagadda
Sep 20, 2021·Drug Discovery Today·Jennifer N Hennigan, Michael D Lynch

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