Digestive Gland from Aplysia depilans Gmelin: Leads for Inflammation Treatment

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Andreia P OliveiraPaula B Andrade

Abstract

The exploitation of marine organisms for human nutritional and pharmaceutical purposes has revealed important chemical prototypes for the discovery of new drugs, stimulating compounds isolation and syntheses of new related compounds with biomedical application. Nowadays, it is well known that inflammatory processes are involved in many diseases and the interest in the search for marine natural products with anti-inflammatory potential has been increasing. The genus Aplysia belongs to the class Gastropoda, having a wide geographical distribution and including several species, commonly known as sea hares. Aplysia depilans Gmelin is usually found in the Mediterranean Sea and in the Atlantic Ocean, from West Africa to the French coast. In these marine organisms, most of the digestion and nutrient absorption occurs in the digestive gland. This work aimed to explore the chemical composition and bioactivity of the methanol extract from A. depilans digestive gland. Therefore, fatty acids and carotenoids were determined by GC-MS and HPLC-DAD, respectively. Twenty-two fatty acids and eight carotenoids were identified for the first time in this species. The A. depilans digestive gland revealed to be essentially composed by polyunsaturated...Continue Reading

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Citations

Mar 18, 2017·International Journal of Molecular Sciences·Tânia Costa SilvaDavid Micael Pereira
Mar 19, 2020·Marine Drugs·Conxita Avila
Aug 5, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·João BernardoPaula B Andrade
Dec 30, 2020·Marine Drugs·Conxita Avila, Carlos Angulo-Preckler

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Software Mentioned

Saturn GC / MS workstation
GraphPad Prism

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