Digit Tip Injuries: Current Treatment and Future Regenerative Paradigms

Stem Cells International
Travis J MillerZeshaan N Maan

Abstract

Over the past several decades there has been a profound increase in the understanding of tissue regeneration, driven largely by the observance of the tremendous regenerative capacity in lower order life forms, such as hydra and urodeles. However, it is known that humans and other mammals retain the ability to regenerate the distal phalanges of the digits after amputation. Despite the increased knowledge base on model organisms regarding regenerative paradigms, there is a lack of application of regenerative medicine techniques in clinical practice in regard to digit tip injury. Here, we review the current understanding of digit tip regeneration and discuss gaps that remain in translating regenerative medicine into clinical treatment of digit amputation.

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Citations

Jul 6, 2020·BMC Musculoskeletal Disorders·Anand O Masson, Roman J Krawetz
Dec 20, 2020·Cell·Carlos López-Otín, Guido Kroemer
May 28, 2021·Current Opinion in Genetics & Development·Mekayla A Storer, Freda D Miller

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Methods Mentioned

BETA
amputations
amputation

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