Digital image processing: a useful tool in the analysis of lung injuries caused by chronic inhalation of agricultural herbicides.

Environmental Science and Pollution Research International
Claudio Pedrassoli JuniorRenata Calciolari Rossi

Abstract

The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used in agriculture to control various weeds. The objective of this study was to use the digital image processing method to identify alveolar lesions in the lungs of rats submitted to chronic 2,4-dichlorophenoxyacetic acid (2,4-D) inhalation exposure. We used forty adult male Wistar rats. The rats were divided into four groups: control group (CG), low concentration group (LCG), medium concentration group (MCG), and high concentration group (HCG). In a 6-month exposure period, we used two boxes connected to ultrasonic nebulizers for herbicide spraying. After this period, the rats were euthanized for the collection and study of lung tissue. For each image, counts of injuries and blisters were performed automatically using a methodology based on digital image processing techniques. For analysis of the results, an electronic database (Excel®) was created. We used the Pearson method for correlation analysis; values of p <0.05 were considered significant. In the evaluation of healthy alveoli, we recorded positive and significant correlations between analysis from a pathologist and computational analysis. In the evaluation of injured alveoli, we recorded a positive but non...Continue Reading

References

Jan 10, 2004·Medical Physics·Ingrid C SluimerBram van Ginneken
Nov 15, 2007·Environmental Toxicology·Ismail Celik, Yasin Tuluce
Jun 9, 2017·Proceedings of SPIE·Awais MansoorMarius George Linguraru
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