PMID: 9423724Jan 10, 1998Paper

Digital ischemia and gangrene due to red blood cell aggregation induced by acquired dysfibrinogenemia

Journal of Vascular Surgery
H C KwaanJ W Kauffman

Abstract

Digital gangrene was observed in a patient who had angiographic findings of digital arterial occlusion. The patient's blood showed a marked red blood cell aggregation with rouleaux formation in long chains, which could not be dispersed at shear rates up to 200 sec-1. Studies of the patient's blood revealed the presence of an abnormal fibrinogen capable of aggregating normal red blood cells. This fibrinogen was found by Raman spectroscopy to have an increased alpha-helical content, whereas the beta-sheet content was decreased. Defibrinogenation therapy with ancrod resulted in a dramatic symptomatic relief. The disappearance of the abnormal fibrinogen 6 months later and an absence of a family history indicate that this dysfibrinogenemia was acquired.

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Citations

Mar 24, 1999·Current Opinion in Hematology·D A Andrews, P S Low
May 28, 2017·Clinical Hemorheology and Microcirculation·Gregorio CaimiEugenia Hopps
Jun 5, 2021·Biophysical Journal·Elahe JavadiSafa Jamali

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