Digital phenotyping: towards replicable findings with comprehensive assessments and integrative models in bipolar disorders

International Journal of Bipolar Disorders
Ulrich W Ebner-PriemerE Severus

Abstract

Digital phenotyping promises to unobtrusively obtaining a continuous and objective input of symptomatology from patients' daily lives. The prime example are bipolar disorders, as smartphone parameters directly reflect bipolar symptomatology. Empirical studies, however, have yielded inconsistent findings. We believe that three main shortcomings have to be addressed to fully leverage the potential of digital phenotyping: short assessment periods, rare outcome assessments, and an extreme fragmentation of parameters without an integrative analytical strategy. To demonstrate how to overcome these shortcomings, we conducted frequent (biweekly) dimensional and categorical expert ratings and daily self-ratings over an extensive assessment period (12 months) in 29 patients with bipolar disorder. Digital phenotypes were monitored continuously. As an integrative analytical strategy, we used structural equation modelling to build latent psychopathological outcomes (mania, depression) and latent digital phenotype predictors (sleep, activity, communicativeness). Combining gold-standard categorical expert ratings with dimensional self and expert ratings resulted in two latent outcomes (mania and depression) with statistically meaningful facto...Continue Reading

References

Apr 1, 1979·Acta Psychiatrica Scandinavica·P BechO J Rafaelsen
Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Jun 27, 2012·The Australian and New Zealand Journal of Psychiatry·Michael BauerPeter C Whybrow
Nov 20, 2012·Annual Review of Clinical Psychology·Timothy J Trull, Ulrich Ebner-Priemer
Apr 11, 2013·Nature Reviews. Neuroscience·Katherine S ButtonMarcus R Munafò
May 13, 2015·Nature Biotechnology·Sachin H JainJohn S Brownstein
Sep 24, 2015·Bipolar Disorders·Maria Faurholt-JepsenLars Vedel Kessing
Mar 16, 2016·Assessment·Aaron J Fisher, James F Boswell
Jul 1, 2016·Proceedings of the National Academy of Sciences of the United States of America·Anders EklundHans Knutsson
Sep 20, 2016·Clinical Psychological Science : a Journal of the Association for Psychological Science·Anda GershonJamie M Zeitzer
Jan 24, 2017·IEEE Transactions on Bio-medical Engineering·N PalmiusM De Vos
Sep 8, 2018·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Thomas R Insel
May 10, 2019·Nature Reviews. Genetics·Vivian TamDavid Meyre
Oct 23, 2019·The Lancet. Psychiatry·Ulrich Ebner-Priemer, Philip Santangelo

❮ Previous
Next ❯

Citations

Jul 7, 2021·Experimental Neurology·Markus ReichertAndreas Meyer-Lindenberg
Aug 10, 2021·Frontiers in Psychiatry·Morten Lindbjerg TønningLars Vedel Kessing

❮ Previous
Next ❯

Software Mentioned

ChronoRecord
movisensXS
BipoSense
Mplus

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Related Papers

Der Nervenarzt
Nils Opel, Tim Hahn
Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Lisa A Marsch
© 2021 Meta ULC. All rights reserved