Data in animals indicate that large amounts of digitalis potentiate arterial baroreflexes and that this factor may be important for the cardiovascular effects of the drug. To determine if arterial baroreflex potentiation also exists after administration of therapeutic doses of digitalis in man, we studied how stimulation and deactivation of arterial baroreceptors by phenylephrine and nitroglycerin injection affect heart rate and how stimulation and deactivation of carotid baroreceptors by neck suction and pressure affects blood pressure and heart rate. The study was performed in 29 normotensive or hypertensive subjects before and after injection of Lanatoside C (0.8 mg i.v.). Baroreceptor stimulation reduced heart rate and blood pressure, while baroreceptor deactivation increased both of these variables. The bradycardic and hypotensive effect of baroreceptor stimulation increased significantly after digitalis both in normotensive and hypertensive subjects. However, the tachycardic and hypertensive responses to baroreceptor deactivation were not affected by digitalis. Thus, therapeutic doses of digitalis in man enhance baroreceptor reflexes, and both the heart rate and the blood pressure reflex effects are involved. However, the...Continue Reading
An electrogenic sodium pump and baroreceptor function in normotensive and spontaneously hypertensive rats
Reflex regulation of arterial pressure during sleep in man. A quantitative method of assessing baroreflex sensitivity
Influence of cardiovascular diseases upon the results of the cardiovascular reflex tests in diabetic and nondiabetic subjects
Decreased baroreflex sensitivity in patients with stable coronary artery disease is correlated with the severity of coronary narrowing
Effects of digoxin on time domain measures of heart rate variability in patients with stable chronic cardiac failure: withdrawal and comparison group studies
Effects of new calcium channel blocker, azelnidipine, and amlodipine on baroreflex sensitivity and ambulatory blood pressure
Correlation between atrial natriuretic peptide and baroreflex sensitivity in patients with congestive heart failure
Circadian variation of heart rate variability in postinfarction patients with and without life-threatening ventricular tachyarrhythmias
The short-term effects of digoxin in patients with right ventricular dysfunction from pulmonary hypertension
Effect of oral digoxin in high-risk heart failure patients: a pre-specified subgroup analysis of the DIG trial
Left ventricular dysfunction and altered autonomic activity: a possible link to sudden cardiac death
Effects of acetylstrophanthidin on baroreflex sensitivity in patients with acute myocardial infarction
A reduction in the correlation dimension of heartbeat intervals precedes imminent ventricular fibrillation in human subjects
Acute effects of digoxin on total systemic vascular resistance in congestive heart failure due to dilated cardiomyopathy: a hemodynamic-hormonal study
Effect of Digoxin on Ventricular Remodeling and Responsiveness of beta-Adrenoceptors in Chronic Volume Overload
Is there an expanded role for digoxin in patients with heart failure and sinus rhythm? An antagonist viewpoint
Supine Parasympathetic Withdrawal and Upright Sympathetic Activation Underly Abnormalities of the Baroreflex in Postural Tachycardia Syndrome: Effects of Pyridostigmine and Digoxin.
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Antianginal Drugs: Mechanisms of Action
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