Digitalis drugs and vulnerability to ventricular fibrillation

European Journal of Pharmacology
W W BrooksB LOWN

Abstract

The effect of acetylstrophanthidine (AS), a rapid-acting digitalis-like agent, on the ventricular fibrillation (VF) threshold was examined in normal and denervated chloralose-anesthetized dogs. In neurally intact dogs an intravenous bolus of AS (0.075 mg/kg) increased the VF threshold up to a maximum 50% (P less than 0.01) within 30 min after injection. The augmented VF threshold following intravenous administration of AS was not altered by vagotomy. Bilateral stellectomy in vagotomized dogs, as well as carotid sinus and aortic arch denervations, however, prevented the AS induced increase in VF threshold. In neurally intact dogs beta-adrenergic blockade with propranolol (0.25 mg/kg) precluded AS effects. These data suggest that the increase in the VF threshold resulting from AS administration in the normal canine ventricle is due to withdrawal of sympathetic tone mediated via the baroreceptor reflex. The direct effect of AS on the myocardium is to decrease the VF threshold.

References

Nov 1, 1985·Acta Radiologica: Diagnosis·T W MorrisB Cioffi

Citations

May 20, 1976·The New England Journal of Medicine·B LOWN, R Verrier
Feb 10, 1977·The New England Journal of Medicine·B LOWNC Gaughan
Jun 1, 1977·Circulation Research·P J SchwartzB LOWN
Jul 1, 1975·The American Journal of Cardiology·W W Tse, J HAN
Feb 1, 1974·The American Journal of Cardiology·D P ZipesG K MOE
Sep 1, 1965·The American Journal of Cardiology·W M Daggett, M L Weisfeldt
Apr 5, 1973·The New England Journal of Medicine·T W Smith
Feb 10, 1967·Annals of the New York Academy of Sciences·B R LucchesiJ L Stickney
Oct 1, 1969·Circulation Research·R E Ten Eick, B F Hoffman
May 20, 1954·The New England Journal of Medicine·B LOWN, S A LEVINE
Jun 1, 1964·Circulation Research·J HANG K MOE
May 1, 1965·Medicine·E BRAUNWALDJ ROSS
Aug 1, 1960·The American Journal of Cardiology·B LOWNF D MOORE

Related Concepts

Ventricular Fibrillation
Electrolytes
K-Strophanthidin
Sympathetic Nervous System
Ouabain
Digitalis Glycosides
Angelman Syndrome
Structure of Stellate Ganglion
Neonatal Abstinence Syndrome
Denervation

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