Digitalis glycosides: a discussion of the similarities and differences in actions and existing controversies
The writing of this review was initiated to answer the question of whether differences in the actions of the various digitalis glycosides exist and to discuss current controversies in the research area of the digitalis glycosides. Data obtained in our laboratory indicated that the effect of digoxin on postganglionic cardiac sympathetic neural discharge in the minute prior to the occurrence of arrhythmia differed from that of ouabain. This raised the question of whether data published in other laboratories would support the contention that differences in glycosides do exist. To answer this question, a review of the literature was begun. Our survey of these studies are cited in the tables of this review. These tables summarize the actions of glycosides in vivo and in vitro in different animal models. The reader should bear in mind that the data included within the tables do not represent an inclusive summary of all studies in the literature. For detailed review articles, the reader is referred to the following references: Gillis et al; Gillis and Quest; Roberts et al; Lathers and Roberts; Farah and Alousi; Benthe; Levitt et al; Smith and Haber; Somberg; Lee and Klaus; Mason; Schwartz. Furthermore the summary of the results for ea...Continue Reading
Beta-Adrenoceptor studies. 4. Influence of albumin on in vitro beta-adrenoceptor blocking and antiarrhythmic properties of propranolol, pindolol, practolol and metoprolol
Effect of arrhythmogenic doses of deslanoside on the uptake of monoamines in brain tissue and in cardiac tissue
Inefficacy of digitalis in the control of heart rate in patients with chronic atrial fibrillation: beneficial effect of an added beta adrenergic blocking agent
A possible molecular mechanism of the action of digitalis: ouabain action on calcium binding to sites associated with a purified sodium-potassium-activated adenosine triphosphatase from kidney
The antiarrhythmic effects of quinidine and propranolol in the ouabain-intoxicated spinally transected cat
The effects of external cations and ouabain on the intracellular sodium activity of sheep heart Purkinje fibres
Calcium influx and spontaneous phasic contractions of portal veins after treatment with reserpine, 6-hydroxydopamine, and cocaine
Nonuniform cardiac sympathetic nerve discharge: mechanism for coronary occlusion and digitalis-induced arrhythmia
Effect of acute stress and ouabain administration on adrenal catecholamine content and cardiac function of rats pretreated with diazepam.
Effects of reserpine on water, cation, and norepinephrine contents of cardiovascular tissues of normotensive dogs
An electrogenic sodium pump and baroreceptor function in normotensive and spontaneously hypertensive rats
Some observations on the interaction between cardiac glycosides and reserpine in the heart and central nervous system.
The modification of inotropic action of ouabain by 6-hydroxydopamine and alpha-methyl-p-tyrosine in dogs
Are the sympathetic neural effects of digoxin and quinidine involved in their action on cardiac rhythm?
Comparative studies of the influence of various K+ concentration on the action of K-strophthidin, digitoxin and strophanthidin-3-bromoacetate on papillary muscle and on membrane-ATPSA of guinea pig hearts
Evidence for a dissociation between positive inotropic effect and inhibition of the Na+-K+-ATPase by ouabain, cassaine and their alkylating derivatives
Association and dissociation rate constants of the complexes between various cardiac monoglycosides and Na, K-ATPase
Inhibition of Na+, K+-ATPase and digitalis action: dissociation from inotropic effects and its role in digitalis cardiotoxicity
Effect of quinidine and pronethalol on acetylstrophanthidin-induced ventricular arrhythmia in cats treated with reserpine
The effect of the vagus nerves on the bradycardia and ventricular arrhythmias induced by digitoxin and digoxin
Myocardial and adrenal medullary catecholamine responses. I. Response to rapid digitalization with acetylstrophanthidin
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