Digitalis: neurally mediated arrhythmogenic and coronary vasoconstrictor properties

Journal of Clinical Pharmacology
J C Somberg

Abstract

Studies of digitalis have revealed an appreciable role of the autonomic nervous system in the modulation of the cardiovascular toxicity of digitalis. Neuraxis transection experiments and studies using digitalis compounds that fail to enter the central nervous system suggest that centers located in the floor of the fourth cerebral ventricle play a substantial part in the neural arrhythmogenic effects of the digitalis glycosides. Electrical stimulation of the area postrema in partially digitalized animals, not otherwise manifesting ventricular arrhythmias, elicits ventricular tachycardia. Neuraxis transection experiments and studies with a charged digitalis derivative also suggest localization of the coronary vasoconstrictive properties of digitalis to the area postrema. The results suggest that this region of the brainstem is sensitive to a neurally active substance, digitalis, causing peripheral sympathetic effects of considerable consequence.

References

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Citations

Oct 31, 2006·Pharmacology & Therapeutics·Robert L Hamlin
Mar 2, 2006·Clinical Therapeutics·Claudio PedoneUNKNOWN GIFA Investigators
Jun 26, 2001·Clinical and Experimental Pharmacology & Physiology·B A NairD D Gutterman
Jan 15, 1990·The Medical Journal of Australia·P R Pentel, D M Salerno
Apr 16, 2021·Journal of the American Veterinary Medical Association·Robert TrujanovicMark D Kittleson

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