Digitalis therapy is associated with higher comorbidities and poorer prognosis in patients undergoing ablation of atrial arrhythmias: data from the German Ablation Registry

Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Gerrit FrommeyerLars Eckardt

Abstract

Digitalis glycosides are employed for rate control of atrial fibrillation. Recent studies suggested potential harmful effects of digitalis monotherapy and combination with antiarrhythmic drugs. The aim of the present study was to assess the prevalence and potential impact of digitalis therapy on outcome in patients undergoing catheter ablation of supraventricular arrhythmias. The German Ablation Registry is a nationwide, prospective registry with a 1-year follow-up investigating 12,566 patients receiving catheter ablations of supraventricular arrhythmias in 52 German centres. The present analysis focussed on pharmacotherapy in 8608 patients undergoing catheter ablation of atrial tachycardia, atrial fibrillation, or atrial flutter. Patients receiving digitalis therapy (n = 417) were older and presented a significantly increased prevalence of comorbidities including coronary artery disease, heart failure, diabetes, and pulmonary disease. One-year mortality was significantly higher in digitalis-treated patients (4.7% vs. 1.3%, p < 0.001), most strikingly in patients undergoing ablation of atrial flutter. This effect was maintained after adjustment for important risk factors. Similar results were obtained for as the combined endpoi...Continue Reading

References

Feb 20, 1997·The New England Journal of Medicine·UNKNOWN Digitalis Investigation Group
Feb 18, 2003·JAMA : the Journal of the American Medical Association·Saif S RathoreHarlan M Krumholz
Aug 9, 2007·European Journal of Clinical Pharmacology·Pär HallbergUNKNOWN RIKS-HIA group
Nov 16, 2011·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN PALLAS Investigators
Nov 29, 2012·European Heart Journal·Matthew G WhitbeckClaude S Elayi
Oct 19, 2013·Journal of Cardiovascular Electrophysiology·Martin SchmidtEllen Hoffmann
Aug 16, 2014·Journal of the American College of Cardiology·Mintu P TurakhiaPaul A Heidenreich
Nov 8, 2014·Circulation. Arrhythmia and Electrophysiology·Stefan H HohnloserStuart J Connolly
Feb 26, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Gerrit FrommeyerLars Eckardt
May 6, 2015·European Heart Journal·Mate VamosStefan H Hohnloser
Nov 4, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paulus KirchhofKatja Zeppenfeld
Nov 20, 2016·International Journal of Cardiology·Gerrit FrommeyerLars Eckardt
Jan 10, 2017·European Heart Journal·Udo BavendiekJohann Bauersachs
Jan 19, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Sonia BuschJohannes Brachmann
Mar 10, 2018·Journal of the American College of Cardiology·Renato D LopesUNKNOWN ARISTOTLE Committees and Investigators
Aug 8, 2018·European Heart Journal·Christopher J RushJohn J V McMurray
Aug 31, 2018·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jan-Hendrik van den BruckDaniel Steven

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Citations

Dec 1, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Maura M ZyllaDierk Thomas
Mar 8, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ann-Kathrin RahmEberhard Scholz
Apr 5, 2020·Kardiologiia·K V PotapovaN V Amineva

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