Digitalized spiral drawing in Parkinson's disease: A tool for evaluating beyond the written trace

Human Movement Science
Jérémy DannaSerge Pinto

Abstract

One of the current scientific challenges is to propose novel tools and tasks designed to identify new motor biomarkers in Parkinson's disease (PD). Among these, a focus has placed on drawing tasks. Independently from clinical ratings, this study aimed to evaluate the pen movement and holding in digitalized spiral drawing in individuals with PD without and with medical treatment and in healthy controls. A three-step data-driven analysis was conducted. First, the effects of spatial and temporal constraints on several variables were determined. Second, the relationship between handedness and dominance of PD symptoms was investigated for the most relevant variables. Finally, a third analysis was conducted to assess the occurrence of changes associated with PD. The first analysis revealed that the number of velocity peaks and pen altitude variations were the most relevant variables in spiral drawing for evaluating the effect of the disease and medication. The second analysis revealed that the effect of medication was present for the movement fluency only, when spirals with spatial constraints were produced at a spontaneous speed by the hand on the side of dominant PD signs. Finally, the third analysis showed that the effect of medic...Continue Reading

References

Feb 1, 1972·Journal of the Neurological Sciences·J E McLennanR S Schwab
Jan 1, 1997·Neuropsychology·A Cronin-Golomb, A E Braun
Jul 1, 1997·Experimental Neurology·H L TeulingsC H Adler
Jul 2, 1999·Neuropsychologia·A W Van GemmertG E Stelmach
Feb 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·M G LongstaffG E Stelmach
Mar 7, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Cynthia L ComellaUNKNOWN and The Dystonia Study Group
Apr 11, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gertrúd TamásAnita Kamondi
Nov 18, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·A W A Van GemmertG E Stelmach
Aug 18, 2004·IEEE Transactions on Bio-medical Engineering·Arash SalarianKamiar Aminian
Apr 26, 2005·Journal of Neuroscience Methods·Xuguang LiuPeter G Bain
Aug 18, 2006·Lancet Neurology·Ruth DjaldettiEldad Melamed
Oct 5, 2007·Parkinsonism & Related Disorders·Mirthe M PonsenHenk W Berendse
Dec 13, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Rachel Saunders-PullmanSeth L Pullman
Mar 18, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·J Jankovic
May 9, 2008·Journal of Neuroscience Methods·Hongzhi WangSeth L Pullman
Jun 11, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Jan StochlEvzen Růzicka
Jan 19, 2010·Parkinsonism & Related Disorders·Kaili StanleyRachel Saunders-Pullman
Jan 30, 2010·Parkinsonism & Related Disorders·Alice NieuwboerStephan P Swinnen
May 5, 2010·Journal of Neuroscience Methods·Jerker WestinTorgny Groth
Jun 24, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Peter H Kraus, Arndt Hoffmann
Sep 24, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Matthew J BarrettG Frederick Wooten
Jan 12, 2011·Archives of Neurology·Yuncheng WuJoseph Jankovic
Jun 30, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Dietrich HaubenbergerMark Hallett
Jun 19, 2013·Journal of Neurology·Sara RosenblumIlana Schlesinger
Jun 25, 2013·Neurochemistry International·Sushil SharmaManuchair Ebadi
Oct 22, 2013·JAMA : the Journal of the American Medical Association·UNKNOWN World Medical Association
Dec 11, 2013·Human Movement Science·Vietminh Paz-VillagránJean-Luc Velay
Aug 27, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Alban LetanneuxSerge Pinto
Aug 16, 2015·Neurorehabilitation and Neural Repair·Evelien NackaertsElke Heremans
Oct 31, 2015·Neurodegenerative Disease Management·Serge Pinto, Jean-Luc Velay
Feb 15, 2016·Artificial Intelligence in Medicine·Peter DrotárMarcos Faundez-Zanuy
Oct 13, 2016·PloS One·Marta San LucianoRachel Saunders-Pullman
Apr 19, 2017·Artificial Intelligence in Medicine·Aleksander SadikovDejan Georgiev

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