Digitization of clinical and epidemiological data from the Kyoto Collection of Human Embryos: maternal risk factors and embryonic malformations

Congenital Anomalies
Tomomi KamedaNobuhiko Suganuma

Abstract

Understanding the causes of congenital anomalies is of prime importance to develop management and/or prevention strategies. It is widely accepted that the occurrence of congenital malformations in fetuses and neonates is heavily correlated with maternal genetic makeup and lifestyle. However, very few epidemiologic analyses have been conducted on the embryonic developmental period because of the rarity of data available. Instigated in 1961, the Kyoto Collection of Human Embryos comprises approximately 45,000 specimens of embryos and fetuses. The collection's most unique feature is that most specimens were added to the collection along with epidemiologic information on the respective mothers. This is the first report on the digitization of data from the collection. A total of 22,262 embryonic specimens were selected on the basis of data integrity. Data related to the embryos were then classified according to the following criteria: developmental stage, sampling period, geographical area, maternal determinant, and external malformation. Results indicate that 7.8% of the embryos exhibit external anomalies and 92.2% are without anomalies. The three most common anomalies were nuchal bleb, holoprosencephaly and spina bifida. A special...Continue Reading

References

Apr 26, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Brian Freeman
Aug 27, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Shigehito YamadaKohei Shiota
Mar 23, 2005·Neurology·D F WyszynskiUNKNOWN Antiepileptic Drug Pregnancy Registry
Aug 24, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·P BaumannR J Sokol
Apr 3, 2008·Pediatrics·Joyce A MartinShae R Sutton
Feb 21, 2009·Paediatric and Perinatal Epidemiology·Eric A MillerUNKNOWN National Birth Defects Prevention Study
Mar 11, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Ari SafirEyal Sheiner
Apr 2, 2010·International Journal of Epidemiology·Hannah BlencoweJoy Lawn
Apr 7, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J RankinR Bell
Jun 26, 2010·American Journal of Medical Genetics. Part a·Emanuele LeonciniPierpaolo Mastroiacovo
Jul 20, 2010·Birth Defects Research. Part A, Clinical and Molecular Teratology·Rebecca J SchmidtUNKNOWN National Birth Defects Prevention Study
Apr 19, 2011·Lancet·Vicki FlenadyUNKNOWN Lancet's Stillbirths Series steering committee
Jun 17, 2011·The Journal of Infectious Diseases·S E ReefS Cochi
Feb 3, 2012·Head & Face Medicine·Miho KagurashoTetsuya Takakuwa

❮ Previous
Next ❯

Citations

Oct 18, 2015·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Tohoru KanahashiTetsuya Takakuwa
Sep 15, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Peter F NicholYukio Saijoh
Nov 4, 2015·PloS One·Rosana Rosseto de OliveiraThais Aidar de Freitas Mathias
Feb 3, 2012·Head & Face Medicine·Miho KagurashoTetsuya Takakuwa
Apr 18, 2018·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Shigehito YamadaMasatoshi Hagiwara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Obstetrics and Gynecology
Shigehito YamadaK Shiota
Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
Yoshimasa MatsudaK Shiota
© 2022 Meta ULC. All rights reserved