Digoxin--a redundant drug in congestive cardiac failure

Cardiovascular Drugs and Therapy
P A Poole-Wilson, K Robinson

Abstract

Controversy continues concerning the use of digoxin as a positive inotropic agent in the treatment of heart failure in patients in sinus rhythm. Digoxin is properly used to control the heart rate in patients in atrial fibrillation. The findings from 14 uncontrolled and 6 controlled clinical trials have been examined. Digoxin does exert a small chronic positive inotropic effect. Although some individual patients, particularly those with fluid overload, appear to benefit from digoxin, controlled clinical trials in patients, most of whom have been treated with diuretics, have failed to demonstrate an increase of exercise capacity. No mortality trial has been attempted. Digoxin has the potential to be harmful in patients with ischemic heart disease. Alternative and safer therapies have been shown to be equal or superior to digoxin.

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Citations

Jan 1, 1997·Cardiovascular Drugs and Therapy·S Sasayama
Dec 1, 1993·Cardiovascular Drugs and Therapy·P A Poole Wilson
Oct 1, 1993·Journal of the American College of Cardiology·P A Poole-Wilson
Aug 1, 1994·Journal of the American College of Cardiology·P A Poole-Wilson
Apr 25, 1992·BMJ : British Medical Journal·P A Poole-Wilson, D Lindsay
Jul 1, 1993·British Heart Journal·P Wilmshurst
Apr 1, 1996·Aging : Clinical and Experimental Research·P U Carbonin, G Zuccalà
Apr 24, 2014·Molecular Pharmaceutics·Elnaz GozalpourJan B Koenderink
Nov 15, 1993·The Medical Journal of Australia·A Bobik

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