Digoxin compliance in patients from general practice

British Journal of Clinical Pharmacology
G D Johnston, D G McDevitt

Abstract

1. Compliance with digoxin therapy has been assessed in a group of fifty patients receiving the drug in general practice but not attending hospital. 2. Compliance was estimated by comparing plasma digoxin concentrations before and after a 10 day period of measured digoxin consumption and by tablet counting. 3. Twelve patients had plasma concentrations which increased by more than 0.4 ng/ml during monitored intake and eight other patients took less than 80% of their tablets. These twenty patients were considered non-compliant. 4. A further three patients in whom plasma digoxin levels were zero when first seen but increased substantially during the run-in period were also adjudged non-compliant. 5. Non-compliance with prescribed digoxin dosage occurred, therefore, in 46% of the patients studied.

References

Jan 1, 1978·British Journal of Clinical Pharmacology·G D Johnston, D G McDevitt
Jan 1, 1978·British Heart Journal·G D JohnstonD G McDevitt
Jan 15, 1972·Lancet·K OjalaP Reissell
Aug 12, 1972·Lancet·T R ShawJ Hamer
Jul 1, 1974·British Heart Journal·S G CarruthersD G McDevitt
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Jul 1, 1974·Circulation·E Steiness
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Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·O Impivaara, E Iisalo
Aug 1, 1980·European Journal of Clinical Pharmacology· Wilholm B-E
Feb 1, 1980·Irish Journal of Medical Science·G D Johnson, D G McDevitt
Jan 1, 1989·Irish Journal of Medical Science·G D Johnston
Jul 9, 1988·BMJ : British Medical Journal·C M AndersonA M Wood
Apr 28, 1979·British Medical Journal
Nov 10, 1979·British Medical Journal
Jan 1, 1983·Current Medical Research and Opinion·A J Taggart, D G McDevitt
Jan 1, 1984·British Journal of Clinical Pharmacology·D R TaylorD G McDevitt
Aug 16, 1985·Klinische Wochenschrift·M MiddekeH Holzgreve
Feb 1, 1985·Scandinavian Journal of Primary Health Care·S Magnusson
Jan 1, 1985·Acta Medica Scandinavica·O Impivaara
Jan 1, 1981·British Journal of Clinical Pharmacology·A J TaggartD G McDevitt
Jan 1, 1983·Upsala Journal of Medical Sciences·K BomanJ E Ogren

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