Digoxin Is Associated With Increased All-cause Mortality in Patients With Atrial Fibrillation Regardless of Concomitant Heart Failure: A Meta-analysis

Journal of Cardiovascular Pharmacology
Zhi-Quan WangYi-Gang Li

Abstract

For decades, digoxin has been widely used to control ventricular rate in atrial fibrillation (AF). However, it remains controversial as to whether digoxin is associated with increased mortality in AF. In this study, we searched relevant studies that were published before December 1, 2014, in PubMed, EMBASE, and the Cochrane central databases. We systematically reviewed the references and performed a meta-analysis of 8 carefully selected studies with 302,738 patients who were included for the final analysis. It was shown that digoxin use was associated with increased risk of all-cause mortality in AF overall [hazard ratio (HR) = 1.375, 95% confidence intervals (CI), 1.201-1.574, P = 0.0001]. Subgroup analysis further revealed that digoxin was associated with increased all-cause mortality in patients with AF, which was complicated by heart failure (HF) (HR = 1.201, CI, 1.074- 1.344, P = 0.001), and in those subjects without HF (HR = 1.172, CI, 1.148-1.198, P = 0.0001). Sensitivity analyses found results to be robust. Our findings indicated that digoxin use was associated with significantly increased all-cause mortality in patients with AF regardless of concomitant HF. We suggest that digoxin should not be preferentially used over...Continue Reading

References

Nov 1, 1991·Circulation·M Gheorghiade, D Ferguson
May 1, 1993·Postgraduate Medical Journal·G Y LipF G Dunn
Oct 1, 1993·Journal of the American College of Cardiology·R A Kelly, T W Smith
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Mar 9, 1999·Circulation·P J Hauptman, R A Kelly
Jun 24, 2004·Circulation·Mihai GheorghiadeWilson S Colucci
Apr 21, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Julio A ChirinosYeon S Ahn
Aug 9, 2007·European Journal of Clinical Pharmacology·Pär HallbergUNKNOWN RIKS-HIA group
Mar 27, 2012·The American Journal of Medicine·Eric H YangJohn M Criley
Nov 29, 2012·European Heart Journal·Matthew G WhitbeckClaude S Elayi
Aug 16, 2014·Journal of the American College of Cardiology·Mintu P TurakhiaPaul A Heidenreich
Nov 22, 2014·Circulation. Arrhythmia and Electrophysiology·James V FreemanAlan S Go

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Citations

Apr 14, 2016·Journal of Pharmacy Practice·Michael J Scalese, Dominick J Salvatore
Apr 17, 2018·Pacing and Clinical Electrophysiology : PACE·Richard CharnigoClaude S Elayi
Aug 2, 2018·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Thomas F Whayne
Jun 27, 2019·Current Cardiology Reviews·Filipe FerrariRicardo Stein
Oct 19, 2021·Frontiers in Cardiovascular Medicine·Xiaoxu WangKun Zhao
Nov 3, 2021·International Journal of Immunopathology and Pharmacology·Ciprian Ilie RoscaDaniel Florin Lighezan
Nov 9, 2021·Cardiovascular Drugs and Therapy·J TriskaY Birnbaum
Oct 20, 2021·European Heart Journal. Cardiovascular Pharmacotherapy·Wern Yew DingGregory Y H Lip

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