Digoxin lowers the incidence of prostate cancer: A nationwide population-based study.

Journal of the Chinese Medical Association : JCMA
Tzu-Ping LinWilliam J S Huang

Abstract

In vitro studies have confirmed that cardiac glycosides can induce apoptosis in both hormone-dependent and -independent prostate cancer (PCa) cell lines. The aim of this study was to investigate the incidence of PCa among patients treated with and without digoxin using a nationwide population-based database in Taiwan. We retrieved data of men aged 30 years or older who were newly diagnosed with heart failure between January 1998 and December 2003 from the National Health Insurance program database in Taiwan. We divided the patients into digoxin users and non-digoxin users. Kaplan-Meier curves and Cox proportional hazard analysis were used to examine the risk of subsequent PCa between the digoxin and non-digoxin groups. The mean ± SD follow-up (years) periods in the digoxin and non-digoxin groups were 8.6 ± 1.78 and 8.3 ± 1.75, respectively. The cumulative incidence of PCa during the follow-up period was 3.5% (147/4233) in the non-digoxin group compared with 3.0% (65/2154) in the digoxin group. The log-rank test revealed that the digoxin group had a similar incidence of PCa to the non-digoxin group (p = 0.18). After adjusting for age, benign prostatic hyperplasia, and comorbidities, Cox proportional hazard regression analysis sh...Continue Reading

References

Mar 12, 2008·Molecular Interventions·Robert A NewmanKeith I Block
Aug 15, 2008·Cancer Research·Reza Beheshti ZavarehAaron D Schimmer
Nov 21, 2008·Proceedings of the National Academy of Sciences of the United States of America·Huafeng ZhangGregg L Semenza
Aug 24, 2011·Molecular Cancer Therapeutics·Ioannis PrassasEleftherios P Diamandis
Feb 1, 2012·Clinical Epidemiology·Michael F Leitzmann, Sabine Rohrmann
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Aug 14, 2013·BJU International·Evelyn M FlahavanThomas I Barron

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Methods Mentioned

BETA
biopsy

Software Mentioned

PASW Statistics
SPSS

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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