PMID: 6156329Jan 1, 1980Paper

Digoxin serum concentration measurement in patients with suspected digitalis-induced arrhythmias

Journal of Cardiovascular Pharmacology
R BernabeiP Carbonin

Abstract

The serum digoxin concentration (SDC) was measured in 100 consecutive patients with suspected digitalis-induced arrhythmias. In 24 (toxic group) of these subjects arrhythmias disappeared after glycoside withdrawal. The mean (+/- SD) SDC was 2.88 +/- 1.89 ng/ml in the toxic group and 1.00 +/- 0.61 in the nontoxic group (p less than 0.0001). With respect to digitoxicity, the SDC showed a predictive accuracy rate of 88%, a specificity rate of 89%, and a sensitivity rate of 62%. Since our results were obtained from symptomatic patients, we observed a better predictive accuracy rate than other authors, who studied symptomatic and asymptomatic subjects. The high percentage of false-negatives makes it impossible to consider the SDC by itself a diagnostic test for digitoxicity. However, the SDC is a useful test since all other parameters are less sensitive and/or less rapid indicators of probable digitalis intoxication.

Citations

Sep 2, 1987·European Journal of Pharmacology·P Abete, M VASSALLE
Nov 1, 1996·Archives of Gerontology and Geriatrics·L CarosellaGruppo Italiano di Farmacovigilanza nell'Anziano
Mar 21, 1998·The Journal of Pharmacy and Pharmacology·P SrinivasuD Rambhau
Dec 1, 1987·The American Journal of the Medical Sciences·G D ParkR D Feldman
May 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh
Mar 1, 1984·Progress in Cardiovascular Diseases·T W SmithJ D Marsh

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Cardiac Arrhythmia
Digitalis Glycosides
Mapluxin

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