PMID: 702246Oct 1, 1978Paper

Digoxin therapy in low-birth-weight infants with patent ductus arteriosus

The Journal of Pediatrics
W BermanM J Maisels

Abstract

Digoxin therapy was evaluated retrospectively in a group of 30, and prospectively in a group of 16 low-birth-weight, premature infants with cardiorespiratory symptoms due to persistent patency of the ductus arteriosus. The response to decongestive therapy was equivocal. Digoxin levels in serum varied between 1.5 and 13 ng/ml. Digoxin half-life in serum exceeded three days in four patients. Fourteen of the combined group of 46 infants had signs of toxicity of digoxin. High dosage, inadvertent overadministration, and variable clearance of digoxin, as well as special characteristics of the patients studied, are postulated as explanations for the high incidence of toxicity. This study suggests that digoxin therapy in low-birth-weight, premature infants with patent ductus arteriosus is not without risk.

References

Jun 1, 1978·The Journal of Pediatrics·W BermanJ Musselman
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Nov 1, 1972·Circulation·W T DunganG V Dalrymple

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Citations

Jul 1, 1980·European Journal of Clinical Pharmacology·L Nyberg, G Wettrell
Apr 1, 1984·Pediatric Cardiology·A R HastreiterE Chow-Tung
Jan 1, 1988·Indian Journal of Pediatrics·S Singh
Apr 20, 2000·Indian Journal of Pediatrics·S S Kothari
Jan 1, 1982·Pharmacology & Therapeutics·B M Assael
Nov 1, 1993·Archives of Disease in Childhood·N Archer
Apr 2, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·W E Benitz
Nov 1, 1987·European Journal of Pediatrics·H Stopfkuchen
Nov 1, 1993·Early Human Development·V Y Yu
Jun 1, 1986·The Journal of Pediatrics·M K Park
May 1, 1986·Acta paediatrica Scandinavica·L Gortner, D Hellenbrecht
Sep 1, 1979·The Journal of Pediatrics·T Gould, R J Roberts
May 1, 1983·Acta paediatrica Scandinavica·B P Lundell, L O Boréus
Apr 1, 1982·Journal of Pharmacokinetics and Biopharmaceutics·W BermanR Shortencarrier
Mar 4, 2021·Seminars in Fetal & Neonatal Medicine·Koert de WaalMartin Kluckow

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