Dihalohydration of Alkynols: A Versatile Approach to Diverse Halogenated Molecules

European Journal of Organic Chemistry
Samantha M GibsonTom D Sheppard

Abstract

In this paper we outline how dihalohydration reactions of propargylic alcohols can be used to access a wide variety of useful halogenated building blocks. A novel procedure for dibromohydration of alkynes has been developed, and a selection of dichloro and dibromo diols and cyclic ethers were synthesized. The dihalohydration of homo-propargylic alcohols provides a useful route to 3-halofurans, which were shown to readily undergo cycloaddition reactions under mild conditions. Finally, a novel ring expansion of propargylic alcohols containing a cyclopropylalkyne provides access to halogenated alkenylcyclobutanes.

References

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Methods Mentioned

BETA
column chromatography
NMR

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