Dihydralazine treatment limits liver injury after hemorrhagic shock in rats

Critical Care Medicine
Rene SchmidtBenedikt H J Pannen

Abstract

Impaired hepatic perfusion after hemorrhagic shock frequently results in hepatocellular dysfunction associated with increased mortality. This study characterizes the effect of the vasodilators dihydralazine and urapidil on hepatocellular perfusion and integrity after hemorrhagic shock and resuscitation. Prospective, randomized, controlled experimental study. University experimental laboratory. Male Sprague-Dawley rats. To register systemic and regional hepatic hemodynamics, rats (n=6 per group) were instrumented and randomly assigned to the following groups: shock+vehicle; shock+dihydralazine (1.5 mg/kg); or shock+urapidil (3 mg/kg). After 1 hr of hemorrhagic shock, animals were resuscitated for 5 hrs and mean arterial pressure was maintained at 70+/-5 mm Hg by administration of dihydralazine or urapidil. To evaluate hepatic heme oxygenase-1 expression and liver injury (determination of levels of alanine and aspartate aminotransferase [ALT, AST] and histology), an additional series of experiments with six animals per group was performed. At the end of each experiment, animals were killed and blood and liver tissue was obtained for subsequent analyses. Dihydralazine increased cardiac output and portal and hepatic microvascular f...Continue Reading

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Citations

Jan 1, 2013·Journal of Anesthesia·Iosifina I KarmaniolouNikolaos F Arkadopoulos
Nov 15, 2007·Nitric Oxide : Biology and Chemistry·Alexander HoetzelBenedikt H J Pannen
Jul 17, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hila BarashRinat Abramovitch
Mar 8, 2008·Pharmacological Reviews·Nader G Abraham, Attallah Kappas
Jul 21, 2020·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Anoek L I van LeeuwenCharissa E van den Brom
Sep 12, 2008·The Journal of Pharmacology and Experimental Therapeutics·Christian I SchwerRene Schmidt

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