PMID: 9554537Apr 29, 1998Paper

Dihydro-5-azacytidine and cisplatin in the treatment of malignant mesothelioma: a phase II study by the Cancer and Leukemia Group B

Cancer
B L SamuelsN J Vogelzang

Abstract

In a prior Cancer and Leukemia Group B (CALGB) Phase II trial of patients with advanced, previously untreated mesothelioma, dihydro-5-azacytidine (DHAC) demonstrated a 17% response rate, including 1 complete response, with only mild myelosuppression. This Phase II study (CALGB 9031) was conducted to determine the effectiveness of and toxicities that would result from adding cisplatin to DHAC administered to the same patient population. Thirty-six patients were treated with concurrent DHAC at 1500 mg/m2/day for 5 days by continuous infusion and cisplatin 15 mg/m2 daily for 5 days. Therapy was repeated every 3 weeks. Cisplatin was to be increased to 20 mg/m2 daily in subsequent cycles if toxicity was minimal. Therapy was continued until disease progression or excessive toxicity mandated discontinuation. Overall, 5 objective responses were observed in 29 evaluated patients (objective response rate, 17%). The median duration of response was 6.6 months. Median survival was 6.4 months, with a median time to clinical failure of 2.7 months. The major toxicity noted was significant chest/pericardial pain, as was observed with DHAC alone. There were 2 early deaths of unknown cause on Days 9 and 17 of therapy, respectively. Significant le...Continue Reading

Citations

Nov 9, 2011·Chinese Journal of Cancer·Ting-Xiu XiangQian Tao
Apr 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Robert A KratzkeUNKNOWN Cancer and Leukemia Group B
May 31, 2011·Trends in Pharmacological Sciences·Roberto E Favoni, Tullio Florio
Oct 14, 2009·Seminars in Thoracic and Cardiovascular Surgery·Stacey Su
Oct 9, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Annarita DestroMassimo Roncalli
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter EllisUNKNOWN Lung Cancer Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care
May 17, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Camillo PortaLuciano Mutti
Dec 11, 2002·The Surgical Clinics of North America·Sunil Singhal, Larry R Kaiser
Jul 21, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Sandra Tomek, Christian Manegold

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