Dihydro-Resveratrol Ameliorates Lung Injury in Rats with Cerulein-Induced Acute Pancreatitis

Phytotherapy Research : PTR
Ze-Si LinHong-Jie Zhang

Abstract

Acute pancreatitis is an inflammatory process originated in the pancreas; however, it often leads to systemic complications that affect distant organs. Acute respiratory distress syndrome is indeed the predominant cause of death in patients with severe acute pancreatitis. In this study, we aimed to delineate the ameliorative effect of dihydro-resveratrol, a prominent analog of trans-resveratrol, against acute pancreatitis-associated lung injury and the underlying molecular actions. Acute pancreatitis was induced in rats with repetitive injections of cerulein (50 µg/kg/h) and a shot of lipopolysaccharide (7.5 mg/kg). By means of histological examination and biochemical assays, the severity of lung injury was assessed in the aspects of tissue damages, myeloperoxidase activity, and levels of pro-inflammatory cytokines. When treated with dihydro-resveratrol, pulmonary architectural distortion, hemorrhage, interstitial edema, and alveolar thickening were significantly reduced in rats with acute pancreatitis. In addition, the production of pro-inflammatory cytokines and the activity of myeloperoxidase in pulmonary tissues were notably repressed. Importantly, nuclear factor-kappaB (NF-κB) activation was attenuated. This study is the f...Continue Reading

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Citations

Mar 16, 2017·Phytotherapy Research : PTR·Pratibha AnchiChandraiah Godugu
Nov 18, 2017·Molecular Nutrition & Food Research·Yixuan XiaSiu Wai Tsang
Apr 25, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Laura GamanMarilena Gilca
Feb 6, 2020·The Journal of Pharmacy and Pharmacology·Vaishnavi SundarTamizhselvi Ramasamy
Mar 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Veronika JarosovaJaroslav Havlik
Jan 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shahram AgahJavad Heshmati
Feb 20, 2021·Clinics and Research in Hepatology and Gastroenterology·Dong WuJiaming Qian
Dec 23, 2020·Annual Review of Food Science and Technology·Ian OesterleBenedikt Warth
Feb 25, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lakshmi Priya PasariChandraiah Godugu

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