Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling.

PloS One
Lifeng JiaYupeng Shen

Abstract

Developing drugs that can effectively block STAT3 activation may serve as one of the most promising strategy for cancer treatment. Currently, there is no putative STAT3 inhibitor that can be safely and effectively used in clinic. In the present study, we investigated the potential of dihydroartemisinin (DHA) as a putative STAT3 inhibitor and its antitumor activities in head and neck squamous cell carcinoma (HNSCC). The inhibitory effects of DHA on STAT3 activation along with its underlying mechanisms were studied in HNSCC cells. The antitumor effects of DHA against HNSCC cells were explored both in vitro and in vivo. An investigation on cooperative effects of DHA with cisplatin in killing HNSCC cells was also implemented. DHA exhibited remarkable and specific inhibitory effects on STAT3 activation via selectively blocking Jak2/STAT3 signaling. Besides, DHA significantly inhibited HNSCC growth both in vitro and in vivo possibly through induction of apoptosis and attenuation of cell migration. DHA also synergized with cisplatin in tumor inhibition in HNSCC cells. Our findings demonstrate that DHA is a putative STAT3 inhibitor that may represent a new and effective drug for cancer treatment and therapeutic sensitization in HNSCC p...Continue Reading

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Citations

Apr 12, 2019·Medicinal Research Reviews·Xin SunJianbin Zhang
Jun 24, 2017·Medicinal Research Reviews·Yin Kwan WongJigang Wang
Jun 24, 2017·Cell Communication and Signaling : CCS·Farhad SeifMohammadali Bahar
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Jul 30, 2019·Frontiers in Pharmacology·Weixiao AnShousong Cao
Jun 11, 2020·Cancers·Mariacarmela SantarpiaRafael Rosell
Mar 7, 2021·Medicina·Suhas G Kshirsagar, Rammohan V Rao
Jun 21, 2021·Medicinal Research Reviews·Yuqing MengJigang Wang
Jul 15, 2021·Acta Biochimica Et Biophysica Sinica·Mingrui JiangDaorong Wang

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Methods Mentioned

BETA
Immunoprecipitation
Assay
Enzyme-linked Immunosorbent
transfections
FACS
xenograft
flow cytometry
transfection

Software Mentioned

Image J
Stattic
CalcuSyn

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