Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer.

Journal of Experimental & Clinical Cancer Research : CR
Fei ZhangYing-Bin Liu

Abstract

Patients with metastatic or relapsed gallbladder cancer generally have a poor prognosis. Therefore, targeting metastasis is one arm of therapeutic strategies to treat gallbladder cancer. Levels of translationally controlled tumor protein (TCTP) were measured in samples of gallbladder cancer by immunohistochemical staining. Wound healing, migration and invasion assays were used to investigate the motility of cells. Western blot assay was used to investigate the levels of TCTP and other proteins. Liver metastasis models and lung metastasis models were established to investigate the inhibitory effect of Dihydroartemisinin on gallbladder cancer metastasis. TCTP is aberrantly expressed in gallbladder cancer patients and associated with metastasis and a poor prognosis. Depleting TCTP significantly inhibited gallbladder cancer cell migration and invasion. We found that Dihydroartemisinin as a potent inhibitor of TCTP inhibited TCTP-dependent cell migration and invasion by reducing cell division control protein 42 homolog (Cdc42) activation. In addition, in mice with xenografted tumors, treatment with Dihydroartemisinin decreased gallbladder cancer cell metastases and improved survival. These findings provide new insights into the ther...Continue Reading

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Citations

Mar 8, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Jiaqi WangYingbin Liu
Jun 9, 2019·Journal of Experimental & Clinical Cancer Research : CR·Nan LinRuiyun Xu
Jul 11, 2020·Cells·Ulrich-Axel Bommer, Adam Telerman
Sep 5, 2019·Journal of Experimental & Clinical Cancer Research : CR·Fei ZhangYingbin Liu
Sep 13, 2017·Journal of Experimental & Clinical Cancer Research : CR·Zihang XuXiao Chen
Dec 13, 2018·Anti-cancer Drugs·Nelson Siukei LamJames C G Doery
Nov 30, 2018·Technology in Cancer Research & Treatment·Ming-Wei Chen, Xue-Jian Wu
Sep 21, 2019·Technology in Cancer Research & Treatment·Li Q ZhangLing P Zhao
Jun 12, 2018·Analytical Cellular Pathology (Amsterdam)·Cailing JiangYuxian Bai
Apr 21, 2019·European Journal of Pharmacology·Shumin LiYuxian Bai
Aug 23, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Chuanxi ZhengChongqi Tu
May 5, 2021·Journal of Pharmacological Sciences·Jingfei ZhengFang Zhang
Sep 24, 2020·Journal of Biomolecular Structure & Dynamics·Ibrahim MalamiImaobong C Etti
Jul 15, 2021·Acta Biochimica Et Biophysica Sinica·Mingrui JiangDaorong Wang
Jan 23, 2020·Current Medicinal Chemistry·Shunqin ZhuWanhong Liu
Nov 3, 2021·Journal of Medicinal Chemistry·Sahil AroraRaj Kumar

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Methods Mentioned

BETA
PCR
scraping
confocal microscopy
transfection
light microscopy
gene knockdown
GTPase
surgical resection

Software Mentioned

ImageJ
SPSS
Xenogen
LuminaXR
IVIS
Volocity

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