Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial.

PLoS Medicine
Prasanna JagannathanGrant Dorsey

Abstract

Intermittent preventive treatment of malaria in pregnancy (IPTp) with dihydroartemisinin-piperaquine (IPTp-DP) has been shown to reduce the burden of malaria during pregnancy compared to sulfadoxine-pyrimethamine (IPTp-SP). However, limited data exist on how IPTp regimens impact malaria risk during infancy. We conducted a double-blinded randomized controlled trial (RCT) to test the hypothesis that children born to mothers given IPTp-DP would have a lower incidence of malaria during infancy compared to children born to mothers who received IPTp-SP. We compared malaria metrics among children in Tororo, Uganda, born to women randomized to IPTp-SP given every 8 weeks (SP8w, n = 100), IPTp-DP every 8 weeks (DP8w, n = 44), or IPTp-DP every 4 weeks (DP4w, n = 47). After birth, children were given chemoprevention with DP every 12 weeks from 8 weeks to 2 years of age. The primary outcome was incidence of malaria during the first 2 years of life. Secondary outcomes included time to malaria from birth and time to parasitemia following each dose of DP given during infancy. Results are reported after adjustment for clustering (twin gestation) and potential confounders (maternal age, gravidity, and maternal parasitemia status at enrolment).T...Continue Reading

Associated Clinical Trials

Jun 13, 2014·Grant Dorsey, M.D, Ph.D., Grant Dorsey, M.D, Ph.D.

References

Mar 1, 1994·The Journal of Infectious Diseases·F NostenN J White
Feb 8, 2005·PLoS Medicine·Nicholas J White
Nov 2, 2005·PLoS Medicine·Theonest K MutabingwaPatrick E Duffy
Jan 26, 2007·The Lancet Infectious Diseases·Meghna DesaiRobert D Newman
Feb 19, 2008·British Journal of Clinical Pharmacology·Irwin LawTimothy M E Davis
Apr 15, 2008·Pharmacology & Therapeutics·Ronald N Hines
Jun 5, 2008·Expert Opinion on Drug Metabolism & Toxicology·Marissa J ScandlynRhonda J Rosengren
Aug 30, 2008·Nature Reviews. Immunology·Eleanor N Fish
Sep 11, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Norbert G SchwarzMartin P Grobusch
Jul 10, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew CairnsDaniel Chandramohan
Apr 27, 2010·The Lancet Infectious Diseases·Sabra L KleinAndrew Pekosz
Jan 5, 2011·The Journal of Infectious Diseases·Azucena BardajíClara Menéndez
Jul 1, 2011·The Journal of Clinical Endocrinology and Metabolism·Peter J O'ShaughnessyPaul A Fowler
May 23, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Antoine RachasAndré Garcia
Jun 8, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Tina Ming-Na LeeSunil Parikh
Jun 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jack S RichardsJames G Beeson
Aug 3, 2013·The Journal of Infectious Diseases·Kwaku Poku AsanteDaniel Chandramohan
Jun 27, 2014·The Journal of Infectious Diseases·Maximilian Muenchhoff, Philip J R Goulder
Mar 18, 2015·The American Journal of Tropical Medicine and Hygiene·Moses R KamyaGrant Dorsey
May 13, 2015·Antimicrobial Agents and Chemotherapy·Brioni R MooreTimothy M E Davis
Jun 3, 2015·Open Forum Infectious Diseases·Tobias O ApinjohEric A Achidi
Jul 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Danica A HelbBryan Greenhouse
Feb 3, 2016·FEMS Microbiology Reviews·James G BeesonJack S Richards
Mar 11, 2016·The New England Journal of Medicine·Abel KakuruGrant Dorsey
Apr 28, 2016·MBio·Sabra L KleinPeter Aaby
Aug 23, 2016·Nature Reviews. Immunology·Sabra L Klein, Katie L Flanagan

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Citations

Sep 26, 2019·Immunological Reviews·Margaret E Feeney
May 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Sara BorghiTaia T Wang
Nov 11, 2020·Nature Immunology·Saborni ChakrabortyTaia T Wang
Mar 23, 2021·Current Epidemiology Reports·Matthew M IppolitoJonathan J Juliano

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