Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study.

The Lancet Infectious Diseases
Chanaki AmaratungaRick M Fairhurst

Abstract

Artemisinin resistance in Plasmodium falciparum threatens to reduce the efficacy of artemisinin combination therapies (ACTs), thus compromising global efforts to eliminate malaria. Recent treatment failures with dihydroartemisinin-piperaquine, the current first-line ACT in Cambodia, suggest that piperaquine resistance may be emerging in this country. We explored the relation between artemisinin resistance and dihydroartemisinin-piperaquine failures, and sought to confirm the presence of piperaquine-resistant P falciparum infections in Cambodia. In this prospective cohort study, we enrolled patients aged 2-65 years with uncomplicated P falciparum malaria in three Cambodian provinces: Pursat, Preah Vihear, and Ratanakiri. Participants were given standard 3-day courses of dihydroartemisinin-piperaquine. Peripheral blood parasite densities were measured until parasites cleared and then weekly to 63 days. The primary outcome was recrudescent P falciparum parasitaemia within 63 days. We measured piperaquine plasma concentrations at baseline, 7 days, and day of recrudescence. We assessed phenotypic and genotypic markers of drug resistance in parasite isolates. The study is registered with ClinicalTrials.gov, number NCT01736319. Betwee...Continue Reading

Associated Clinical Trials

References

Dec 10, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mey Bouth DenisDoung Socheat
Dec 21, 2006·Tropical Medicine & International Health : TM & IH·Mey Bouth DenisPascal Ringwald
Jan 21, 2010·The Journal of Infectious Diseases·Kasia StepniewskaNicholas J White
Aug 24, 2010·The Journal of Infectious Diseases·Eva Maria HodelFrédéric Ariey
Oct 14, 2011·The New England Journal of Medicine·Arjen M DondorpChristopher V Plowe
Apr 6, 2012·The New England Journal of Medicine·Ronnatrai RueangweerayutUNKNOWN Pyronaridine–Artesunate Study Team
Sep 4, 2012·The Lancet Infectious Diseases·Chanaki AmaratungaRick M Fairhurst
Nov 28, 2012·The Lancet Infectious Diseases·Nicholas J White
Mar 2, 2013·The Journal of Infectious Diseases·Tatiana M Lopera-MesaRick M Fairhurst
Jul 31, 2014·The New England Journal of Medicine·Nicholas J WhiteF Joel Leong
Jul 31, 2014·The New England Journal of Medicine·Elizabeth A AshleyUNKNOWN Tracking Resistance to Artemisinin Collaboration (TRAC)
Jul 31, 2014·The New England Journal of Medicine·David L SaundersUNKNOWN Royal Cambodian Armed Forces
Jan 20, 2015·Nature Genetics·Olivo MiottoDominic P Kwiatkowski
Apr 17, 2015·The Lancet Infectious Diseases·Donelly A van Schalkwyk, Colin J Sutherland

❮ Previous
Next ❯

Citations

Jan 18, 2016·The Lancet Infectious Diseases·David Saunders, Chanthap Lon
Feb 26, 2016·Molecular Biology and Evolution·Stanislaw J GabryszewskiDavid A Fidock
Apr 15, 2016·Drugs·Brioni R MooreTimothy M E Davis
May 18, 2016·Expert Review of Anti-infective Therapy·Paul N NewtonPhilippe J Guerin
Jun 13, 2016·Trends in Parasitology·Leann TilleyDavid A Fidock
Aug 31, 2016·Nature Microbiology·Alan H FairlambAndrew P Waters
Jun 18, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Aung Pyae PhyoFrancois Nosten
Jul 29, 2016·The New England Journal of Medicine·Umberto D'Alessandro, UNKNOWN PREGACT Study Group
Sep 9, 2016·Scientific Reports·Ian M HastingsKatherine Kay
Sep 11, 2016·FEMS Microbiology Reviews·Charles J Woodrow, Nicholas J White
Oct 30, 2016·Trends in Parasitology·Hannah C SlaterAzra C Ghani
Nov 8, 2016·The Lancet Infectious Diseases·Arjen M Dondorp
Nov 9, 2016·Malaria Journal·Krongkan SrimuangUNKNOWN Tracking Resistance to Artemisinin Collaboration
Feb 10, 2017·Trends in Parasitology·Sarah K VolkmanDaniel L Hartl
May 25, 2016·The American Journal of Tropical Medicine and Hygiene·Philip J Rosenthal
Dec 9, 2016·The American Journal of Tropical Medicine and Hygiene·Valentine DuruDidier Ménard
May 18, 2017·Nature Communications·Celia Miguel-BlancoEsperanza Herreros
Jun 6, 2017·The FEBS Journal·Aung Myint ThuFrançois H Nosten
Mar 16, 2017·Cold Spring Harbor Perspectives in Medicine·Didier Menard, Arjen Dondorp
Feb 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·David LanglaisPhilippe Gros
Apr 8, 2018·Applied Microbiology and Biotechnology·Maciej GrzybekPaweł Lisowski
Apr 21, 2018·Parasite : Journal De La Société Française De Parasitologie·Manel OujiFrançoise Benoit-Vical
Jan 24, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gabriele RossiJean-Marie Kindermans

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.