PMID: 6402199Feb 26, 1983Paper

Dihydrocodeine for breathlessness in "pink puffers"

British Medical Journal
M A JohnsonD M Geddes

Abstract

Eighteen patients with severe breathlessness due to chronic airflow obstruction completed a randomised placebo controlled double blind cross over trial of the effect of dihydrocodeine 15 mg on breathlessness, disability, and exercise tolerance. There were three periods of one week each. During the first two weeks patients were instructed to take dihydrocodeine 15 mg or placebo 30 minutes before exercise as required up to three times daily. During the third week patients received either dihydrocodeine or placebo on alternate days. During the weekly dihydrocodeine period patients were more mobile (pedometer distance increased by 16.8%) and less breathless (daily visual analogue score of breathlessness reduced by 17.8%). This benefit was confirmed by treadmill testing at the end of each treatment period, when maximum distance walked was 16.5% higher and breathlessness 11.8% less after dihydrocodeine compared with placebo. Similar benefit in breathlessness occurred during alternate day treatment. No adverse effects were encountered. Dihydrocodeine 15 mg 30 minutes before exercise offers appreciable benefit to patients with severe breathlessness due to chronic airflow obstruction.

References

Jul 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·T V SantiagoN H Edelman
Apr 25, 1981·Lancet·A A WoodcockD M Geddes
Jun 3, 1982·The New England Journal of Medicine·D Bar-OrJ Good

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Citations

May 1, 1994·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M Farncombe, S Chater
Jan 25, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Raymond ViolaUNKNOWN Supportive Care Guidelines Group of the Cancer Care Ontario Program in Evidence-Based Care
Dec 7, 1995·The New England Journal of Medicine·H L Manning, R M Schwartzstein
Apr 25, 2006·Journal of Palliative Medicine·Egidio Del FabbroEduardo Bruera
Mar 1, 1984·Postgraduate Medical Journal·D M Geddes
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·P J PooleP N Black
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine
Jun 1, 1990·The American Review of Respiratory Disease·G SupinskiM Altose
Jul 23, 2011·American Journal of Respiratory and Critical Care Medicine·Robert B BanzettRichard M Schwartzstein
Feb 18, 2012·American Journal of Respiratory and Critical Care Medicine·Mark B ParshallUNKNOWN American Thoracic Society Committee on Dyspnea
Dec 1, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Hope E UronisAmy P Abernethy
Feb 1, 2009·Expert Review of Respiratory Medicine·Sara BoothShakeeb H Moosavi
Dec 18, 2003·Drug Development and Industrial Pharmacy·Sung-Up ChoiYoung Wook Choi
Jan 1, 1992·Cancer Investigation·M H CohenR G Wadleigh
Sep 5, 2015·British Journal of Clinical Pharmacology·Nicholas T VozorisPaula A Rochon
Jan 1, 1987·British Journal of Diseases of the Chest·P A O'NeillA K Webb
Jun 2, 1998·Cancer Treatment Reviews·C RipamontiE Bruera
Oct 1, 1990·Journal of Pain and Symptom Management·K Cowcher, G W Hanks
Jun 1, 1985·British Journal of Clinical Pharmacology·P A O'NeillR D Stark
Jan 1, 1984·British Journal of Clinical Pharmacology·P A O'NeillR D Stark
Mar 25, 2015·Annals of the American Thoracic Society·Magnus EkströmDavid C Currow
Apr 27, 2016·Expert Review of Respiratory Medicine·Denis E O'DonnellJ Alberto Neder
Mar 13, 2016·European Clinical Respiratory Journal·Charlotte KohbergElisabeth Bendstrup
Mar 27, 2002·International Journal of Epidemiology·Diana R ElbourneAndy Vail
Oct 9, 2014·The American Journal of Hospice & Palliative Care·Miriam J JohnsonDavid C Currow
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Anne Louise JenningsKaren E Broadley
Aug 8, 2008·Current Opinion in Supportive and Palliative Care·David C Currow, Amy P Abernethy
Apr 22, 2010·Current Opinion in Supportive and Palliative Care·Robert Horton, Graeme Rocker
Jul 16, 2016·The European Respiratory Journal·Nicholas T VozorisPaula A Rochon
Dec 29, 1998·The American Journal of Hospice & Palliative Care·G Zeppetella
Feb 6, 2003·The American Journal of Hospice & Palliative Care·Susan B LeGrandNilo I Rivera
Apr 1, 2016·The Cochrane Database of Systematic Reviews·Hayley BarnesRenée Manser
Apr 4, 2013·Expert Review of Respiratory Medicine·Donald A Mahler
Jul 24, 2020·Current Opinion in Supportive and Palliative Care·David Hui, Eduardo Bruera

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