PMID: 8583370Aug 1, 1995Paper

Dihydroetorphine is a mu-receptor-selective ligand

The Journal of Pharmacy and Pharmacology
D X WangB Y Qin

Abstract

The selectivity to opioid receptors of dihydroetorphine, a potent analgesic with only mild physical dependence, was investigated using radioligand binding assay and its analgesic activity in mice determined. The relative affinity ratio of dihydroetorphine to mu-, delta- and kappa- opioid receptors was 333:1:1. The analgesic effect of intracerebro-ventricular injection in mice could be antagonized by the mu-antagonist beta-funaltrexamine but could not be antagonized by delta- and kappa-selective antagonists naltrindole and norbinaltorphimine. We conclude that dihydroetorphine is a selective ligand for the mu-opioid receptor.

References

Apr 1, 1985·British Journal of Pharmacology·R CottonJ R Traynor
Jun 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J MagnanH W Kosterlitz
Apr 9, 1981·European Journal of Pharmacology·B K HandaC F Smith
Oct 26, 1984·Science·G S LingG W Pasternak

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Citations

Feb 2, 2008·Cellular and Molecular Neurobiology·Jin Li
May 20, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Gang YuZe-Hui Gong
Aug 1, 1997·Natural Product Reports·K W Bentley
May 22, 2002·European Journal of Pharmacology·Dauren BiyashevSándor Benyhe
Sep 24, 1999·European Journal of Pharmacology·K O LeeJ R Traynor
Apr 18, 2020·ACS Chemical Neuroscience·Jillian L Kyzer, Cody J Wenthur

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