Dihydroisocoumarins from Radix Glycyrrhizae

Chemistry Central Journal
Songsong ZhaoHongwei Liu

Abstract

Radix Glycyrrhizae is the rhizome of Glycyrrhiza inflata Bat., Glycyrrhiza uralensis Fisch. or Glycyrrhiza glabra L. The present paper describes the isolation and the structural elucidation of three new dihydroisocoumarins obtained from the 70% EtOH extract of Radix Glycyrrhizae. And the cytotoxic activities of these new compounds were also evaluated using four cell lines, subsequently. A pair of new dihydroisocoumarin epimers ((3R,4S)-4,8-dihydroxy-3-methyl-1-oxoisochroman-5-yl)methyl acetate (1) and ((3R,4R)-4,8-dihydroxy-3-methyl-1-oxoisochroman-5-yl)methyl acetate (2) along with a new dihydroisocoumarin (3R,4R)-4,8-dihydroxy-3,5-dimethylisochroman-1-one (3) were isolated from Radix Glycyrrhizae. Their structures were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses, HR-ESI-MSand ECD calculation comparing with those of experimental CD spectra. Cytotoxic activities of the three compounds were evaluated using the HepG2, A549, LoVo and Hela cell lines, respectively. IC50 values indicated compounds 1-3 exhibited moderate or less cytotoxic activity in vitro. Dihydroisocoumarin is not the common components in Radix Glycyrrhizae, a series of dihydroisocoumarin were obtained in this plant coul...Continue Reading

References

Jan 11, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhongping John LinLinyee Shum
Jun 22, 2005·Journal of Pharmaceutical and Biomedical Analysis·Florian RauchensteinerTadato Tani
Jul 4, 2017·Journal of Asian Natural Products Research·Wei ZhengZheng Xiang

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Citations

May 30, 2019·Natural Product Research·Songsong ZhaoZheng Xiang

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Methods Mentioned

BETA
NMR
Circular Dichroism

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