Dihydromyricetin prevents monocrotaline-induced pulmonary arterial hypertension in rats

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Qinghai LiJun Yu

Abstract

Pulmonary artery hypertension (PAH) is a chronic and deadly disease, for which effective medical treatments are lacking. Here, we investigated whether 2R,3R-dihydromyricetin (DHM) could prevent monocrotaline (MCT)-induced PAH in rats. The MCT-injected rats were treated with normal saline or DHM (100mg/kg body weight/d) for 4 weeks, followed by measurements of right ventricular systolic pressure (RVSP), right ventricular hypertrophy index (RVHI), pulmonary arterial remodeling (PAR), and expression levels of IL-6, TNF-α, and IL-10. In vitro, we assessed the role of DHM on IL-6-induced migration of primary human pulmonary arterial smooth muscle cells (HPASMCs). We found that DHM treatment attenuated changes in RVSP, RVHI, and PAR in MCT-injected PAH rats. The observed increase of IL-6 levels in PAH rats was inhibited by DHM treatment. In vitro, DHM pretreatment reduced IL-6-induced HPASMC migration. Furthermore, MCT- and IL-6-mediated increases in MMP9 and P-STAT3 (tyr705) PY-STAT3 levels were suppressed by DHM treatment in vivo and in vitro. These results suggest that DHM could prevent MCT-induced rat PAH and IL-6-induced HPASMC migration through a mechanism involving inhibiting of the STAT3/MMP9 axis.

Citations

Jun 28, 2020·Journal of Cellular Physiology·Jun WangJungang Xie
Nov 10, 2018·Frontiers in Pharmacology·Jingyao ZhangShengju Yang
Jan 27, 2021·International Journal of Molecular Sciences·Carmen De MiguelSantiago Cuevas
Dec 8, 2020·Food Science & Nutrition·Liling WangBentong Liu
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yi HuYongjun Mao
Feb 10, 2021·Antioxidants & Redox Signaling·Santiago Cuevas, Pablo Pelegrín
Jun 26, 2021·The Chinese Journal of Physiology·Jialing WangRu Zhou
Aug 3, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jingnan ChenRunzhi Zhu

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