Abstract
Helicobacter pylori (H. pylori) infection is the world's most common bacterial infection, affecting approximately 50% of the global population. H. pylori is the strongest known risk factor for stomach diseases, including cancer. Hence, treatment for H. pylori infection can help reduce the risk of these diseases. However, the emergence of drug-resistant strains of H. pylori and the occurrence of adverse effects resulting from current therapies have complicated the successful eradication of H. pylori infection. Although various antibiotics that target several bacterial enzymes have been discovered, dihydroorotate dehydrogenase (DHODH) may hold potential for the development of novel anti-H. pylori agents with reduced toxicity and side effects. Here we review the existing literature that has focused on strategies for developing novel therapeutic agents that target the DHODH of H. pylori.
References
Oct 20, 1995·Archives of Biochemistry and Biophysics·R A CopelandT A Patterson
Dec 1, 1994·The Journal of Applied Bacteriology·G L MendzW J O'Sullivan
Aug 7, 1997·Nature·J F TombJ C Venter
Oct 23, 1997·Clinical Microbiology Reviews·B E DunnM J Blaser
Jan 29, 1999·Nature·R A AlmT J Trust
May 21, 1999·Science·A CovacciR Rappuoli
Apr 7, 2000·Clinical Rheumatology·H J AndersM Schattenkirchner
Aug 12, 2000·The Journal of Biological Chemistry·R A CopelandF Hobbs
Mar 21, 2002·Nature Reviews. Cancer·Richard M Peek, Martin J Blaser
Oct 4, 2002·Journal of Medicinal Chemistry·Tasir S HaqueAndrew P Combs
Oct 9, 2002·Nature·Malcolm J GardnerBart Barrell
Apr 21, 2004·The Journal of Biological Chemistry·David R Evans, Hedeel I Guy
Jun 5, 2008·Journal of Medicinal Chemistry·Margaret A PhillipsPradipsinh K Rathod
Dec 10, 2008·The New England Journal of Medicine·Harald NoedlUNKNOWN Artemisinin Resistance in Cambodia 1 (ARC1) Study Consortium
Mar 20, 2009·Journal of Medicinal Chemistry·Ramesh GujjarMargaret A Phillips
Jul 31, 2009·The New England Journal of Medicine·Arjen M DondorpNicholas J White
Jun 24, 2011·Journal of Medicinal Chemistry·Jose M CoteronMargaret A Phillips
Mar 5, 2013·Journal of Medicinal Chemistry·Hélène Munier-LehmannYves L Janin
Aug 10, 2013·Gut Microbes·Francis Mégraud
Jul 17, 2015·Science Translational Medicine·Margaret A PhillipsSusan A Charman
Sep 29, 2015·World Journal of Methodology·Reza GhotaslouYalda Mohammadzadeh Asl
Oct 23, 2016·Lancet·Jyh-Ming LiouUNKNOWN Taiwan Gastrointestinal Disease and Helicobacter Consortium
Apr 2, 2017·The Lancet Infectious Diseases·James S McCarthyJörg J Möhrle
Citations
Dec 19, 2019·Pharmaceutics·Andrés GonzálezÁngel Lanas
Sep 27, 2019·European Journal of Medicinal Chemistry·Donatella BoschiMarco L Lolli
Jul 21, 2021·International Journal of Molecular Sciences·Endah Dwi HartutiDaniel Ken Inaoka
Nov 4, 2021·ACS Chemical Biology·Makoto KawataniHiroyuki Osada