Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer

Biochimica Et Biophysica Acta. Molecular Basis of Disease
Stepana BoukalovaJakub Rohlena

Abstract

Dihydroorotate dehydrogenase (DHODH) is an enzyme of the de novo pyrimidine synthesis pathway that provides nucleotides for RNA/DNA synthesis essential for proliferation. In mammalian cells, DHODH is localized in mitochondria, linked to the respiratory chain via the coenzyme Q pool. Here we discuss the role of DHODH in the oxidative phosphorylation system and in the initiation and progression of cancer. We summarize recent findings on DHODH biology, the progress made in the development of new, specific inhibitors of DHODH intended for cancer therapy, and the mechanistic insights into the consequences of DHODH inhibition.

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M NagyD Thomas
Sep 1, 1992·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R NataleJ Gyves
Jan 1, 1990·Cancer Chemotherapy and Pharmacology·G SchwartsmannM B van Hennik
Jul 2, 1984·European Journal of Biochemistry·M GrégoireD Gravel
Dec 1, 1993·American Journal of Clinical Oncology·R CodyJ Gyves
Jan 1, 1993·Cancer Chemotherapy and Pharmacology·J MarounJ Gyves
Aug 22, 2000·Oncogene·N S ChandelP T Schumacker
Oct 29, 2000·Annals of the Rheumatic Diseases·F C Breedveld, J M Dayer
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Petya DimitrovaHendrik Schulze-Koops
Jan 8, 2003·The Journal of Cell Biology·Jean-Ehrland RicciDouglas R Green
Apr 8, 2003·Cellular and Molecular Life Sciences : CMLS·M Huang, L M Graves
Jun 7, 2003·Science·Lee Zou, Stephen J Elledge
Apr 21, 2004·The Journal of Biological Chemistry·David R Evans, Hedeel I Guy
May 19, 2005·The Journal of Biological Chemistry·Hsiuchen ChenDavid C Chan
Aug 16, 2005·Trends in Molecular Medicine·Monika LöfflerH Anne Simmonds
Sep 7, 2005·Bioorganic & Medicinal Chemistry Letters·Johann LebanRoland Baumgartner
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Frank WeinbergNavdeep S Chandel
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anastasia A KhutornenkoAlexandra G Evstafieva
Nov 3, 2010·British Journal of Pharmacology·H SillA Wölfler
Mar 25, 2011·Nature·Richard Mark WhiteLeonard I Zon
Jul 16, 2011·Arzneimittel-Forschung·Rachna GuptaSuresh Kumar Gupta
Mar 5, 2013·Journal of Medicinal Chemistry·Hélène Munier-LehmannYves L Janin
Apr 16, 2013·Antioxidants & Redox Signaling·Evelina MaranzanaMaria Luisa Genova
Oct 8, 2013·PLoS Pathogens·Marianne Lucas-HouraniPierre-Olivier Vidalain
Apr 22, 2014·Free Radical Biology & Medicine·Martin Hey-MogensenMartin D Brand
May 21, 2014·ELife·William W WheatonNavdeep S Chandel
Jan 30, 2015·Nucleic Acids Research·Andrew N Lane, Teresa W-M Fan
Feb 26, 2015·Expert Review of Clinical Pharmacology·Yara Dadalti Fragoso, Joseph Bruno Bidin Brooks

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Citations

Aug 1, 2020·European Journal of Clinical Investigation·Ana R Coelho, Paulo J Oliveira
Feb 22, 2021·Biochemical and Biophysical Research Communications·Youping ZhangBiao Jiang
Nov 28, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Gabriela L OliveiraPaulo J Oliveira
May 12, 2021·Cancer & Metabolism·Yue ZhouYinglan Zhao
Jun 17, 2021·Journal of Agricultural and Food Chemistry·Asifa KhanMohammad Askandar Iqbal
Jun 15, 2021·Frontiers in Oncology·Wanyan WangJin Huang
Dec 22, 2020·ACS Pharmacology & Translational Science·Christine R CuthbertsonNouri Neamati
Aug 9, 2020·Cell Metabolism·Nick van GastelDavid T Scadden

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