PMID: 5644059May 3, 1968

Dihydroorotic acid dehydrogenase activity of human diploid cell strains

Science
K Wuu, R S Krooth

Abstract

A gene affecting the final two enzymes of uridylic acid biosynthesis does not affect a third, metabolically adjacent enzyme. Similarly, compounds that increase cellular activity for the affected enzymes do not increase activity for the third enzyme. The pyrimidine pathway can be subdivided into groups of concurrently responding enzymes. These groups may be smaller in human cells than they are in microbial cells.

Citations

Jan 1, 1980·Pharmacology & Therapeutics·C Wasternack
Apr 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·S SilagiS A Bruce
Jul 6, 1971·Annals of the New York Academy of Sciences·R S Krooth
Dec 1, 1970·Journal of Cellular Physiology·R S Krooth, E K Sell
Sep 1, 1976·Archives of Biochemistry and Biophysics·J J Chen, M E Jones
Feb 1, 1973·Biochemical Medicine·D M FosterW J O'Sullivan
Jan 1, 1970·Advances in Enzyme Regulation·M E Jones
Sep 1, 1988·Biochemical Pharmacology·G SchwartsmannH M Pinedo

Related Concepts

Amidohydrolases
Barbiturates
Carboxy-Lyases
Diploid Cell
Genetic Carriers
Molecular Genetics (Discipline)
Zinc Orotate
Oxidase
Purine-Pyrimidine Metabolism, Inborn Errors
Transferase

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