PMID: 3762317Oct 27, 1986Paper

Dihydropyridine calcium antagonists depress the amplitude of the plasma melatonin cycle in baboons

Life Sciences
A C MeyerB J Meyer

Abstract

An investigation into the effects of verapamil and some dihydropyridine derivatives on plasma melatonin levels was undertaken in baboons. In a number of separate experiments, groups of young male chacma baboons (mean body weight 13 kg) received intraperitoneal injections of the drugs, under ketamine anaesthesia, roughly 30 minutes prior to the following time points: 1200, 1800, 0000, 0200, 0600 and 1200 h. Lights went off at 1800 h and came on at 0600 h. The drugs used, and their respective dosages (expressed per kg body mass), were verapamil up to 4 mg/kg, nifedipine at 0.2 mg/kg, nitrendipine at 0.5 mg/kg and nisoldipine at 0.1 mg/kg. Blood samples, taken at the said time points, were assayed for melatonin. The nighttime peak of the plasma melatonin cycle was significantly depressed by all three dihydropyridine calcium antagonists (up to 40%), while verapamil, even at the relatively high total dose of 24 mg/kg per day, had no significant effect on the circulating plasma melatonin levels.

References

Dec 4, 1978·Life Sciences·H J Romijn
May 1, 1983·European Heart Journal·P A van Zwieten, P B Timmermans
Feb 23, 1984·Nature·O H Petersen, Y Maruyama
May 9, 1983·Life Sciences·M KavaliersG C Teskey

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Citations

Dec 1, 1987·Cellular and Molecular Neurobiology·D P Cardinali, M I Vacas
Jan 1, 1991·Journal of Neural Transmission. General Section·J B Zawilska, J Z Nowak
Feb 16, 2006·Intensive Care Medicine·Richard S Bourne, Gary H Mills
Oct 3, 1999·Neuroscience Letters·S BenloucifP C Zee
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·S A RivkeesJ Fortman
Nov 1, 1996·Journal of Pineal Research·A Cagnacci
Sep 7, 2005·Cell Biochemistry and Function·Solange C AfecheJosé Cipolla-Neto

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