Dihydropyrimidin-(2H)-ones obtained by ultrasound irradiation: a new class of potential antioxidant agents

European Journal of Medicinal Chemistry
Hélio A StefaniCristina W Nogueira

Abstract

An efficient and simple synthetic protocol for the Biginelli reaction has been developed for the preparation of several new dihydropyrimidinones, under ultrasound irradiation in the presence of NH(4)Cl, in good yields and short reaction time. Some of the synthesized compounds were tested in vitro for their antioxidant activity. All of the selected compounds showed some antioxidant activity. Analogues compounds 3b and 4b exhibited a strong activity against lipid peroxidation induced by Fe + EDTA, while compounds 3b and 3d were the most potent in reducing ROS levels.

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Citations

Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·S ChitraA Thiruvalluvar
Jan 1, 2008·Acta Crystallographica. Section E, Structure Reports Online·N AnuradhaR J Butcher
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·N AnuradhaR J Butcher
Jan 1, 2009·Acta Crystallographica. Section E, Structure Reports Online·N AnuradhaR J Butcher
Feb 21, 2013·Acta Crystallographica. Section E, Structure Reports Online·Rajni KantMadhukar B Deshmukh
Sep 11, 2012·Ultrasonics Sonochemistry·Dian M B RibeiroClaudio M P Pereira
Feb 18, 2016·Oxidative Medicine and Cellular Longevity·Astrida VelenaGunars Duburs
Mar 27, 2012·Journal of Biochemical and Molecular Toxicology·Alana de VasconcelosAlethéa G Barschak
Jan 20, 2018·Molecular Diversity·Behzad Mohammadi, Farahnaz K Behbahani
Mar 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ye LiuZongliang Liu
Mar 27, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Phoebe F Lamie, John N Philoppes
Jan 28, 2020·Current Organic Synthesis·Cedric S GraebinArthur E Kümmerle
Aug 29, 2018·MedChemComm·Franciele S De OliveiraMarcelo G Montes D'Oca
Feb 16, 2021·Archiv der Pharmazie·Ruturajsinh M ValaHitendra M Patel
May 8, 2014·The Journal of Organic Chemistry·Guillermo Fernández de TrocónizFrancisco Palacios

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