Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors

Bioorganic & Medicinal Chemistry Letters
Stefan JarochFiona M McDonald

Abstract

Dihydroquinolines with aminoalkyl side chains have been synthesized and have been shown to be potent n-NOS inhibitors. A marked selectivity versus e-NOS of up to approximately 300-fold was observed, whereas i-NOS was moderately inhibited.

References

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
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Jan 2, 2001·Bioorganic & Medicinal Chemistry Letters·Y LeeR B Silverman
May 1, 2001·Bioorganic & Medicinal Chemistry Letters·H BeatonA V Wallace
Aug 17, 2002·Bioorganic & Medicinal Chemistry Letters·Stefan JarochFiona M McDonald

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Citations

Jan 27, 2004·Bioorganic & Medicinal Chemistry Letters·Stefan JarochHeribert Miklautz
Feb 20, 2014·Chemical Society Reviews·Paramita MukherjeeRichard B Silverman
Jan 30, 2014·Journal of Medicinal Chemistry·Maris A CinelliRichard B Silverman
Aug 23, 2011·Organic Letters·Benjamin L Kohn, Elizabeth R Jarvo

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