Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice

Toxicology and Applied Pharmacology
Yanling GuoXiuping Chen

Abstract

Ulcerative colitis (UC) is a chronic and relapsing inflammatory disorder of the colon and rectum with increasing morbidity in recent years. 15,16-dihydrotanshinone Ӏ (DHT) is a natural product with multiple bioactivities. In this study, we aimed to investigate the protective effect and potential mechanisms of DHT on UC. Dextran sulfate sodium salt (DSS) was administrated in drinking water for 7 days to induce UC in mice. DHT (10 and 25 mg/kg) significantly alleviated DSS-induced body weight loss, disease activity index (DAI) scores, and improved histological alterations of colon tissues. DHT inhibited the myeloperoxidase (MPO) activity, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in colon tissues and decreased serum levels of TNF-α, IL-1β, IL-6, and high-mobility group box 1 (HMGB1). Furthermore, increased expression of kinases receptor-interacting protein 1 (RIP1), RIP3, mixed lineage kinase domain-like protein (MLKL) and decreased expression of caspase-8 in colon tissues were partially restored by DHT. In LPS-stimulated RAW264.7 macrophages, DHT significantly inhibited generation of nitric oxide, IL-6, TNF-α and protein expression of iNOS, COX-2. In addition, increased expression of iNOS, CO...Continue Reading

Citations

May 26, 2020·Journal of Experimental & Clinical Cancer Research : CR·Xiaoping WangYong Wang
Feb 5, 2021·Environmental Pollution·Zijiang YangShiwen Xu
Jun 20, 2021·Drug Development Research·Huanhuan ZhuMinying Wang
Sep 1, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Chuang WuWei Yang
Oct 9, 2021·Journal of Molecular Histology·Siwen TangJinghua Liang

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