Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo.

Acta Biochimica Et Biophysica Sinica
Weipeng BianWenxin Qin

Abstract

Dihydrotanshinone I (DI), a naturally occurring compound extracted from Salvia miltiorrhiza Bunge, has been reported to have cytotoxicity to a variety of tumor cells. In this study, we investigated its anti-angiogenic capacity in human umbilical vein endothelial cells. DI induced a potent cytotoxicity to human umbilical vein endothelial cells, with an IC(50) value of approximately 1.28 microg/ml. At 0.25-1 microg/ml, DI dose-dependently suppressed human umbilical vein endothelial cell migration, invasion, and tube formation detected by wound healing, Transwell invasion and Matrigel tube formation assays, respectively. Moreover, DI showed significant in vivo anti-angiogenic activity in chick embryo chorioallantoic membrane assay. DI induced a 61.1% inhibitory rate of microvessel density at 0.2 microg/egg. Taken together, our results showed that DI could inhibit angiogenesis through suppressing endothelial cell proliferation, migration, invasion and tube formation, indicating that DI has a potential to be developed as a novel anti-angiogenic agent.

Citations

Jan 8, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lan G CoffmanSuzy V Torti
Jan 10, 2013·BMC Complementary and Alternative Medicine·Dayang Erna Zulaikha Awang HamsinYeong Looi Ting
Dec 4, 2012·International Journal of Molecular Sciences·Yong ZhangJunxuan Lü
Oct 15, 2013·Medicinal Research Reviews·Xiuping ChenYitao Wang
Apr 27, 2018·Acta Pharmacologica Sinica·Zhuo-Ming LiPei-Qing Liu
Mar 16, 2021·Frontiers in Pharmacology·Dezhi PanMinhui Li

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