Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells

Carcinogenesis
Cécile GuichardEric Ogier-Denis

Abstract

The search for effective chemopreventive compounds is a major challenge facing research into preventing the progression of cancer cells. The naturally occurring polyphenol antioxidants look very promising, but their mechanism of action still remains poorly understood. Here, we show that 2-(3,4-dihydroxyphenyl)ethanol (DPE), a phenol antioxidant derived from olive oil, induces growth arrest and apoptosis in human colon carcinoma HT-29 cells. The mechanisms involve prolonged stress of the endoplasmic reticulum (ER) leading to the activation of the two main branches of the unfolded protein response (UPR), including the Ire1/XBP-1/GRP78/Bip and PERK/eIF2alpha arms. DPE treatment led to overexpression of the pro-apoptotic factor CHOP/GADD153 and persistent activation of the Jun-NH2-terminal kinase/activator protein-1 signaling pathway. DPE concomitantly modulated the extracellular signal-regulated kinase 1/2 and Akt/PKB pro-survival factors by altering their phosphorylation status as well as inhibiting tumor necrosis factor-alpha-induced nuclear factor-kappaB activation by inactivating the phosphorylation of nuclear factor inhibitor-kappaB kinase. These findings prompted us to investigate the possible involvement of phosphatases in ...Continue Reading

Citations

Apr 21, 2011·Journal of Agricultural and Food Chemistry·Gema Pereira-CaroRaquel Mateos
Mar 5, 2013·Journal of Agricultural and Food Chemistry·Raquel MateosPaul A Kroon
Jun 9, 2011·Molecular Cancer·Maurice Israël, Laurent Schwartz
Nov 1, 2010·Nutrients·David VauzourJeremy P E Spencer
Jun 8, 2011·Future Medicinal Chemistry·Michael VoronkovJeffry B Stock
Dec 7, 2013·Gastroenterology Research and Practice·Weibo ChenYitao Ding
Apr 27, 2010·Nutrition Reviews·Sergio Granados-PrincipalM Carmen Ramirez-Tortosa
May 23, 2012·Journal of Dietary Supplements·Haloom RafehiTom C Karagiannis
Mar 5, 2013·Archives of Biochemistry and Biophysics·Monika Sakowicz-BurkiewiczTadeusz Pawelczyk
Aug 31, 2007·Biochemical and Biophysical Research Communications·Giulia CoronaJeremy P E Spencer
Jun 19, 2009·Molecular Nutrition & Food Research·Roberto FabianiGuido Morozzi
Aug 18, 2009·Molecular Nutrition & Food Research·Giulia CoronaJeremy P E Spencer
Nov 30, 2012·Molecular Nutrition & Food Research·Ivan CasaburiVincenzo Pezzi
Dec 19, 2013·Molecular Nutrition & Food Research·Elena GiordanoFrancesco Visioli
Aug 29, 2014·Molecular Nutrition & Food Research·Oriol A Rangel-ZuñigaAntonio Camargo
Apr 15, 2016·Journal of Experimental & Clinical Cancer Research : CR·Qunying ZhuangZhongning Lin
May 26, 2009·Biochimica Et Biophysica Acta·Wan-Cheol Kim, Chow H Lee
Sep 7, 2016·Journal of Endocrinological Investigation·G TotedaA Perri
Dec 1, 2015·World Journal of Experimental Medicine·Mohamed HassanMossaad Megahed
Dec 15, 2011·Public Health Nutrition·Eduard EscrichMontserrat Solanas
Sep 17, 2008·Biochemical Society Transactions·Cécile GuichardKarl-Heinz Krause
Sep 8, 2018·International Journal of Molecular Sciences·Manuela CipollettiMarco Fiocchetti

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