Diisobutyl phthalate impairs the androgen-dependent reproductive development of the male rat

Reproductive Toxicology
A M SaillenfaitF Gallissot

Abstract

Diisobutyl phthalate (DIBP) is the branched isomer of DBP; DBP side chains have a four-carbon backbone (C4), whereas DIBP has its four-carbon alkyl side chains rearranged into a three-carbon backbone (C3) with a methyl branch. Di-n-butyl phthalate (DBP), and several other ortho-phthalate esters with side-chain lengths of C4-C6, are known to disrupt the androgen-dependent sexual differentiation in the male rat. This study was performed to determine whether in utero exposure to DIBP would induce permanent and dose-responsive alterations of male reproductive development. Pregnant Sprague-Dawley rats were administered olive oil (vehicle control), DIBP or DBP, by gavage on gestation Days 12-21, at doses of 125, 250, 500, 625mgDIBP/(kg day) and 500mgDBP/(kg day). DIBP caused no overt maternal toxicity, nor reduced litter size. Male offspring displayed reduced neonatal anogenital distance (Postnatal day 1, PND) at 250mgDIBP/(kg day) and higher doses, and dose-related retention of areolas/nipples (PND 12-14). Preputial separation (onset of puberty) was delayed in male offspring at 500 and 625mgDIBP/(kg day). Hypospadias, cleft prepuce, and undescended testis were observed in males (11-12 or 16-17 weeks old) exposed in utero to 500 and ...Continue Reading

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Citations

May 28, 2014·Environmental Science and Pollution Research International·Hongwei SunDongbin Wei
May 7, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Johnathan R FurrLeon E Gray
Jan 25, 2013·International Journal of Molecular Sciences·Li-Wen ChangTung-Hu Tsai
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Jul 7, 2009·Reproductive Toxicology·Anne-Marie SaillenfaitFrédéric Gallissot
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Sep 3, 2013·Reproductive Toxicology·Ulf Magnusson, Karl Ljungvall
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